| tryptophan | <amino acid> One of the 20 amino acids found in proteins. Essential dietary component in humans. Precursor of nicotinamide. (18 Nov 1997) |
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| tryptophan 2,3-dioxygenase | An oxidoreductase catalyzing the reaction of l-tryptophan and O2 to produce l-N-formylkynurenine; an adaptive enzyme, the level (in the liver) being controlled by adrenal hormones; a step in tryptophan catabolism; also, a step in the synthesis of NAD+ from tryptophan. Synonym: pyrrolase, tryptophan oxygenase, tryptophan pyrrolase, tryptophanase. (05 Mar 2000) |
| tryptophan 2-methyltransferase | <enzyme> From streptomyces laurentii; catalyses the transfer of a methyl group from s-adenosylmethionine to the c-2 carbon of tryptophan resulting in alpha-methyltryptophan; involved in the biosynthesis of thiostrepton Registry number: EC 2.1.1.- Synonym: s-adenosylmethionine-tryptophan 2-methyltransferase (26 Jun 1999) |
| tryptophan 2-monooxygenase | <enzyme> Forms indole-3-acetamide Registry number: EC 1.13.12.3 (26 Jun 1999) |
| tryptophan C-methyltransferase | <enzyme> Catalyses transfer of methyl group from s-adenosylmethionine to c-3 of tryptophan resulting in beta-methyltryptophan; involved in streptonigrin biosynthesis Registry number: EC 2.1.1.- (26 Jun 1999) |
| tryptophan decarboxylase | <enzyme> An enzyme that catalyses the decarboxylation of l-dopa to dopamine, of l-tryptophan to tryptamine, and of l-hydroxytryptophan to serotonin; important in the biosynthetic pathway of catecholamines and melanin. Synonym: dopa decarboxylase, hydroxytryptophan decarboxylase, tryptophan decarboxylase. (05 Mar 2000) |
| tryptophan desmolase | <enzyme> An enzyme that catalyses the conversion of l-serine and 1-(indol-3-yl)glycerol 3-phosphate to l-tryptophan and glyceraldehyde 3-phosphate. It is a pyridoxal phosphate protein that also catalyses the conversion of serine and indole into tryptophan and water and of indoleglycerol phosphate into indole and glyceraldehyde phosphate. Chemical name: L-Serine hydro-lyase (adding indoleglycerol-phosphate) Registry number: EC 4.2.1.20 (12 Dec 1998) |
| tryptophan hydroxylase | <enzyme> An enzyme that catalyses the hydroxylation of tryptophan to 5-hydroxytryptophan in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of serotonin. Chemical name: L-tryptophan,tetrahydropteridine:oxygen oxidoreductase (5-hydroxylating) Registry number: EC 1.14.16.4 (12 Dec 1998) |
| tryptophan oxygenase | <enzyme> A protohemoprotein. Forms formylkynurenine from l-tryptophan and molecular oxygen. Chemical name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing) Registry number: EC 1.13.11.11 (12 Dec 1998) |
| tryptophan pyrrolase | An oxidoreductase catalyzing the reaction of l-tryptophan and O2 to produce l-N-formylkynurenine; an adaptive enzyme, the level (in the liver) being controlled by adrenal hormones; a step in tryptophan catabolism; also, a step in the synthesis of NAD+ from tryptophan. Synonym: pyrrolase, tryptophan oxygenase, tryptophan pyrrolase, tryptophanase. (05 Mar 2000) |
| tryptophan synthase | <enzyme> An enzyme that catalyses the conversion of l-serine and 1-(indol-3-yl)glycerol 3-phosphate to l-tryptophan and glyceraldehyde 3-phosphate. It is a pyridoxal phosphate protein that also catalyses the conversion of serine and indole into tryptophan and water and of indoleglycerol phosphate into indole and glyceraldehyde phosphate. Chemical name: L-Serine hydro-lyase (adding indoleglycerol-phosphate) Registry number: EC 4.2.1.20 (12 Dec 1998) |
| tryptophan synthetase | <enzyme> An enzyme that catalyses the conversion of l-serine and 1-(indol-3-yl)glycerol 3-phosphate to l-tryptophan and glyceraldehyde 3-phosphate. It is a pyridoxal phosphate protein that also catalyses the conversion of serine and indole into tryptophan and water and of indoleglycerol phosphate into indole and glyceraldehyde phosphate. Chemical name: L-Serine hydro-lyase (adding indoleglycerol-phosphate) Registry number: EC 4.2.1.20 (12 Dec 1998) |
| tryptophan-trna ligase | <enzyme> An enzyme that activates tryptophan with its specific transfer RNA. Chemical name: L-Tryptophan:tRNA(Trp) ligase (AMP-forming) Registry number: EC 6.1.1.2 (12 Dec 1998) |
| tryptophanase | <enzyme> An enzyme that catalyses the conversion of l-tryptophan and water to indole, pyruvate, and ammonia. It is a pyridoxal-phosphate protein, requiring k+. It also catalyses 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogs of l-cysteine, l-serine, and other 3-substituted amino acids. Chemical name: L-Tryptophan indole-lyase (deaminating) Registry number: EC 4.1.99.1 (12 Dec 1998) |
| tryptophanuria | Enhanced urinary excretion of tryptophan. Tryptophanuria with dwarfism, a syndrome of dwarfism, mental defect, cutaneous photosensitivity, and gait disturbance associated with tryptophanuria; autosomal recessive inheritance. (05 Mar 2000) |
| malonyl-CoA-D-tryptophan N-malonyltransferase | <enzyme> From peanuts Registry number: EC 2.3.1.- Synonym: trp-malonyltransferase, malonyl-coenzyme a-d-tryptophan n-malonyltransferase (26 Jun 1999) |
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| peptide-tryptophan 2,3-dioxygenase | <enzyme> Catalyses the oxidation of peptide tryptophan to form peptide formylkynurenine Registry number: EC 1.13.11.26 Synonym: tryptophan pyrrolooxygenase (26 Jun 1999) |
| 4-(4'-hydroxy-3'-methylbut-2'-enyl)-L-tryptophan synthetase | <enzyme> Enzymatic synthesis of above cpd from isopentenylpyrophosphate and tryptophan Registry number: EC 6.- (26 Jun 1999) |
| L-tryptophan 2',3'-oxidase | <enzyme> Specifically catalyses the alpha,beta-dehydrogenation of l- tryptophan derivatives; from chromobacterium violaceum Registry number: EC 1.3.99.- Synonym: l-tryptophan - oxygen 2',3'-oxidoreductase, l-trp-2',3'-oxidase (26 Jun 1999) |