| trimetrexate |
a folic acid antagonist structurally related to methotrexate; it competitively inhibits dihydrofolate reductase. Used investigationally as an antineoplastic; also used in combination with leucovorin to treat Pneumocystis carinii pneumonia in acquired immunodeficiency syndrome, administered intravenously as the glucuronate salt.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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