| trimethoprim |
[USP] an antibacterial closely related to the antimalarial pyrimethamine, acting by inhibiting a step in bacterial folate biosynthesis and effective against various gram-negative and gram-positive bacteria; administered orally in the prophylaxis and treatment of urinary tract infections and the treatment of Pneumocystis carinii pneumonia. It is usually administered in combination with a sulfonamide because the two drugs markedly potentiate each other, and in such combination (e.g., co-trimoxazole) has additional uses including treatment of bronchitis, Shigella enterocolitis, acute otitis media, and traveler's diarrhea. In certain countries, it is used alone as an antimalarial.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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