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"Targeted Gene Repair"¿¡ ´ëÇÑ ´ëÇÑÀÇÇù ÀÇÇпë¾î ¼¼ºÎ °Ë»ö °á°úÀÔ´Ï´Ù
´ëÇÑÀÇÇù ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú :
15
ÆäÀÌÁö:
1
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ÇѱÛ
targeted reconstruction
Ç¥ÀûÀ籸¼º
cleft lip repair
°¥¸²ÀÔ¼úº¹¿ø(¼ú), ±¸¼ø¿º¹¿ø(¼ú)
dural repair
1. °æ(Áú)¸·ºÀÇÕ(¼ú) 2. °æ(Áú)¸·Àç°Ç(¼ú)
dark repair
¾Ï¹ÝÀÀº¹±¸
DNA repair
DNAº¹±¸
epineural repair
1. ½Å°æ¿Ü¸·ºÀÇÕ(¼ú) 2. ½Å°æ¿Ü¸·Àç°Ç(¼ú)
group fascicular repair
½Å°æ¼¶À¯´Ù¹ß±ººÀÇÕ(¼ú)
recombinational repair
ÀçÁ¶ÇÕº¹±¸
repair
1. º¹±¸(¼ú), º¹¿ø(¼ú) 2. Àç°Ç(¼ú) 3. ºÀÇÕ(¼ú) 4. Ä¡À¯
sublethal damage repair
ÁØÄ¡»ç¼Õ»óÄ¡À¯
autosomal gene
º¸Åë¿°»öüÀ¯ÀüÀÚ
additive gene
»ó°¡À¯ÀüÀÚ
allelic gene
´ë¸³À¯ÀüÀÚ
complementary gene
º¸Á·À¯ÀüÀÚ, »óÈ£º¸ÃæÀ¯ÀüÀÚ
control gene
Á¦¾îÀ¯ÀüÀÚ
´ÙÀ½
´ëÇÑÀÇÇù Çʼö ÀÇÇпë¾îÁý »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú :
12
ÆäÀÌÁö:
1
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ÇѱÛ
repair
º¹±¸, ¼öº¹, Ä¡À¯
gene
À¯ÀüÀÚ
allelic gene
´ë¸³À¯ÀüÀÚ
regulator gene
Á¶ÀýÀ¯ÀüÀÚ
structural gene
±¸Á¶À¯ÀüÀÚ
suicide gene
ÀÚ»ìÀ¯ÀüÀÚ
supressor gene
¾ïÁ¦À¯ÀüÀÚ
tumor suppressor gene
Á¾¾ç¾ïÁ¦À¯ÀüÀÚ
gene transfer
À¯ÀüÀÚÀü´Þ
gene translocation
À¯ÀüÀÚÀüÀ§
gene transfection
1.À¯ÀüÀÚÀü´Þ°¨¿°, 2.À¯ÀüÀÚÇÙ³»ÁÖÀÔ
gene therapy
À¯ÀüÀÚ¿ä¹ý
¿¾ ´ëÇÑÀÇÇù ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú :
15
ÆäÀÌÁö:
1
¿µ¹®
ÇѱÛ
targeted reconstruction
Ç¥ÀûÀ籸¼º
cleft lip repair
°¥¸²ÀÔ¼úº¹¿ø(¼ú)
dark repair
¾Ï¹ÝÀÀº¹±¸
DNA repair
µð¿£¿¡À̺¹±¸
dural repair
³ú°æÁú¸·º¹¿ø
epineural repair
½Å°æ¿Ü¸·Àç°Ç¼ú, ½Å°æ¿Ü¸·ºÀÇÕ¼ú
group fascicular repair
½Å°æ¼¶À¯´Ù¹ß±ººÀÇÕ(¹ý)
repair
º¹±¸, ¼öº¹, Ä¡À¯
recombinational repair
ÀçÁ¶ÇÕº¹±¸
sublethal damage repair
ÁØÄ¡»ç¼Õ»óȸº¹
tendon repair
ÈûÁÙºÀÇÕ, °ÇºÀÇÕ
additive gene
»ó°¡À¯ÀüÀÚ
allelic gene
´ë¸³À¯ÀüÀÚ
autosomal gene
º¸Åë¿°»öüÀ¯ÀüÀÚ
gene amplification
À¯ÀüÀÚÁõÆø
´ÙÀ½
¿¾ ´ëÇÑÀÇÇù 2 ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú :
15
ÆäÀÌÁö:
1
¿µ¹®
ÇѱÛ
DNA repair
DNA º¹±¸
DNA repair
DNA ȸº¹
DNA repair system
DNA ·¹Çø®ÄÉÀ̽º ½Ã½ºÅÛ.
DNA repair system
DNA º¸¼ö±â±¸.
SOS repair
SOS[¼Õ»ó]º¹±¸±âÀü
plastic repair on lip
±¸¼øÇü¼º¼ö¼ú(Ï¢âîû¡à÷â¢âú).
recombinational repair
ÀçÁ¶ÇÕ(¼º) DNAº¹±¸
C-fos gene
¾¾-Æ÷½ºÀ¯ÀüÀÚ(ë¶îîí)
C-jun gene
¾¾-ÁØ À¯ÀüÀÚ(ë¶îîí)
DNA mediated gene transfer
DNA ¸Å°³¼ºÀ¯ÀüÀÚÀüÀÌ
DP gene
DPÀ¯ÀüÀÚ
DQ gene
DQÀ¯ÀüÀÚ
DR gene
DRÀ¯ÀüÀÚ
Gag gene
gag À¯Àü(ÀÎ)ÀÚ
Gene therapy
À¯ÀüÀÚÄ¡·á(ö½Öû)
´ÙÀ½
¿¾ ´ëÇÑÀÇÇù 3 ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú :
15
ÆäÀÌÁö:
1
¿µ¹®
ÇѱÛ
targeted reconstruction
Ç¥Àû À籸¼º
dark repair
¾Ï¹ÝÀÀº¹±¸
plastic repair on lip
±¸¼øÇü¼º¼ö¼ú(Ï¢âîû¡à÷â¢âú).
potentially lethal damage repair
ÀáÀçÄ¡»ç¼Õ»óȸº¹
recombinational repair
ÀçÁ¶ÇÕ(¼º) DNAº¹±¸
repair
ȸº¹
repair
¼ö¼±
repair
¼öº¹
repair of radiation damage
¹æ»ç¼± ¼Õ»ó º¹±¸
repair, SOS
SOS(¼Õ»ó)º¹±¸±âÀü
sublethal damage repair
ÁØÄ¡»ç¼Õ»óȸº¹
additive gene
»ó°¡À¯ÀüÀÚ(ßÓÊ¥ë¶îîí).
allelic gene
´ë¸³À¯ÀüÀÚ
aniridia,pax-6 gene
PAX-6 À¯ÀüÀÚ(¡ë¶îîí)
apc gene
APC À¯ÀüÀÚ(¡ë¶îîí)
´ÙÀ½
ÀÌ ¾Æ·¡ ºÎÅÍ´Â °á°ú°¡ ¾ø½À´Ï´Ù.
´ëÇÑÀÇÇù ÀÇÇпë¾î »çÀü °Ë»ö ¸ÂÃã °Ë»ö °á°ú :
0
ÆäÀÌÁö:
1
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ÇѱÛ
´ëÇÑÀÇÇù Çʼö ÀÇÇпë¾îÁý »çÀü °Ë»ö ¸ÂÃã °Ë»ö °á°ú :
0
ÆäÀÌÁö:
1
¿µ¹®
ÇѱÛ
¿¾ ´ëÇÑÀÇÇù ÀÇÇпë¾î »çÀü °Ë»ö ¸ÂÃã °Ë»ö °á°ú :
0
ÆäÀÌÁö:
1
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ÇѱÛ
¿¾ ´ëÇÑÀÇÇù 2 ÀÇÇпë¾î »çÀü °Ë»ö ¸ÂÃã °Ë»ö °á°ú :
0
ÆäÀÌÁö:
1
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ÇѱÛ
¿¾ ´ëÇÑÀÇÇù 3 ÀÇÇпë¾î »çÀü °Ë»ö ¸ÂÃã °Ë»ö °á°ú :
0
ÆäÀÌÁö:
1
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ÇѱÛ
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