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acute monocytic leukaemia <haematology> The most common translocation in this disorder of poorly differentiated monocytic cells involves chromosome region 11q in a large percentage of cases.
The translocation involves a cellular oncogene, c-ets which is mapped to the 11q23-24 region. The most common translocations reported are t(6;11), t(9;11), t(11;17) and t(11;19), of which t(9;11) (p21-22;q23) is by far the most frequently detected and implicated in acute myeloid leukaemia. The cells express CD14 surface antigen, which is diagnostic of monocytic cells.
Acronym: AML
Classification: FAB M5
(07 Apr 1998)
monocytic leukaemia Cancer of the blood due to proliferation of cells of the monocyte series.
Origin: Gr. Haima = blood
(13 Nov 1997)
Schilling type of monocytic leukaemia See: monocytic leukaemia.
(05 Mar 2000)
Naegeli type of monocytic leukaemia A variant of granulocytic leukaemia with monocytosis in the peripheral blood.
Synonym: Naegeli type of monocytic leukaemia.
(05 Mar 2000)
monocytic angina An obsolete term for infectious mononucleosis.
(05 Mar 2000)
monocytic leukemoid reaction Leukocytosis of varying degree, e.g., 30,000 to 40,000 per cu mm, with adult monocytes and immature forms amounting to 30% (or more) of the total number of white blood cells in the circulating blood; may be observed in association with tuberculosis, especially the first infection, miliary type.
(05 Mar 2000)
monocytic leukocytosis An abnormal increase in the number of monocytes in the circulating blood.
Synonym: monocytic leukocytosis.
(05 Mar 2000)
monocytic leukopenia Diminution in the number of monocytes in the circulating blood.
Synonym: monocytic leukopenia, monopenia.
Origin: mono-+ G. Kytos, cell, + penia, poverty
(05 Mar 2000)
equine monocytic ehrlichiosis <veterinary> A febrile disease of horses in North America caused by Ehrlichia risticii and characterised by anorexia, leukopenia, and occasional diarrhoea.
Synonym: Potomac horse fever.
(05 Mar 2000)
subacute Somewhat acute, between acute and chronic.
(18 Nov 1997)
subacute bacterial endocarditis Subacute bacterial endocarditis is usually due to Streptococcus viridans or S. Fecalis.
(05 Mar 2000)
subacute care Medical and skilled nursing services provided to patients who are not in an acute phase of an illness but who require a level of care higher than that provided in a long-term care setting. (jcaho, lexikon, 1994)
(12 Dec 1998)
subacute combined degeneration of the spinal cord A subacute or chronic disorder of the spinal cord, such as that occurring in certain patients with vitamin B12 deficiency, characterised by a slight to moderate degree of gliosis in association with spongiform degeneration of the posterior and lateral columns.
Synonym: combined sclerosis, combined system disease, funicular myelitis, Putnam-Dana syndrome, vitamin B12 neuropathy.
(05 Mar 2000)
subacute glomerulonephritis Undesirable term for glomerulonephritis with proteinuria, haematuria and azotemia persisting for many weeks; renal changes are variable, including those of rapidly progressive and membranoproliferative glomerulonephritis.
Synonym: subacute nephritis.
(05 Mar 2000)
subacute granulomatous thyroiditis Thyroiditis with round cell (usually lymphocytes) infiltration, destruction of thyroid cells, epithelial giant cell proliferation, and evidence of regeneration; thought by some to be a reflection of a systemic infection and not an example of true chronic thyroiditis.
Synonym: de Quervain's thyroiditis, giant cell thyroiditis.
(05 Mar 2000)
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