| somatostatin | <protein> Gastrointestinal and hypothalmic peptide hormone (two forms: 14 and 28 residues), found in gastric mucosa, pancreatic islets, nerves of the gastrointestinal tract, in posterior pituitary and in the central nervous system. Inhibits gastric secretion and motility: in hypothalamus/pituitary inhibits somatotropin release. (18 Nov 1997) |
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| somatostatin-28 convertase | <enzyme> Converts somatostatin-28 to somatostatin-14 and somatostatin-28(1-12) Registry number: EC 3.4.99.- Synonym: s-28 convertase (26 Jun 1999) |
| somatostatinoma | A rare somatostatin-secreting tumour of pancreatic delta cells associated with diabetes mellitus or abnormal glucose tolerance. It is also found in the intestine. Of the reported primary tumours, 60% were found in the pancreas and 40% in the duodenum or jejunum. most patients were between 40 and 60 years of age with a 2:1 ratio of females to males. (12 Dec 1998) |
| receptors, somatostatin | Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behaviour of cells. Somatostatin is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Activated somatostatin receptors on pituitary cells inhibit the release of growth hormone; those on endocrine and gastrointestinal cells regulate the absorption and utilization of nutrients; and those on neurons mediate somatostatin's role as a neurotransmitter. (12 Dec 1998) |
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