| folic acid | <biochemistry> Pteridine derivative that is abundant in liver and green plants and is a growth factor for some bacteria. The biochemically active form is tetrahydrofolate (see folate). (12 Nov 1997) |
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| folic acid antagonist | <pharmacology> A chemical which inhibits a cells capacity to use folic acid and so prevent cell division, for example methotrexate. See: chemotherapy. (12 Nov 1997) |
| folic acid antagonists | Inhibitors of the enzyme, dihydrofolate reductase (tetrahydrofolate dehydrogenase), which converts dihydrofolate (fh2) to tetrahydrofolate (fh4). They are frequently used in cancer chemotherapy. (12 Dec 1998) |
| folic acid conjugate | A folate with three molecules of glutamic acid (pteropterin) instead of one, or with seven (pteroylheptaglutamic acid or vitamin Bc conjugate). (05 Mar 2000) |
| folic acid deaminase | <enzyme> Chemotaxis regulating enzyme; splits folic acid into 6-hydroxymethylpterin and p-aminobenzoylglutamic acid Registry number: EC 3.5.4.- Synonym: folic acid inactivating enzyme, folic acid c9-n10 cleaving enzyme (26 Jun 1999) |
| folic acid deficiency | A nutritional condition produced by a deficiency of folic acid in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anaemia, macrocytic anaemia, and megaloblastic anaemia. It is indistinguishable from vitamin b 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in b 12 deficiency do not occur. (merck manual, 16th ed) (12 Dec 1998) |
| folic acid deficiency anaemia | Anaemia due to deficiency of folic acid, characterised by large-sized red blood cells (macrocytosis) and presence of large nuclei in erythroid precursor cells (megaloblasts) in the bone marrow. (05 Mar 2000) |
| folic acid oxidase | <enzyme> Enzyme from human red blood cell membranes; catalyses oxidation of folic acid to pterin-6-aldehyde plus p-aminobenzoylglutamic acid in presence of h2o2; singlet oxygen is involved Registry number: EC 1.11.- (26 Jun 1999) |
| arrhythmias, slow | Abnormally slow heart rhythms, medically termed bradycardia. (12 Dec 1998) |
| slow | To go slower; often with up; as, the train slowed up before crossing the bridge. 1. Moving a short space in a relatively long time; not swift; not quick in motion; not rapid; moderate; deliberate; as, a slow stream; a slow motion. 2. Not happening in a short time; gradual; late. "These changes in the heavens, though slow, produced Like change on sea and land, sidereal blast." (Milton) 3. Not ready; not prompt or quick; dilatory; sluggish; as, slow of speech, and slow of tongue. "Fixed on defense, the Trojans are not slow To guard their shore from an expected foe." (Dryden) 4. Not hasty; not precipitate; acting with deliberation; tardy; inactive. "He that is slow to wrath is of great understanding." (Prov. Xiv. 29) 5. Behind in time; indicating a time earlier than the true time; as, the clock or watch is slow. 6. Not advancing or improving rapidly; as, the slow growth of arts and sciences. 7. Heavy in wit; not alert, prompt, or spirited; wearisome; dull. Slow is often used in the formation of compounds for the most part self-explaining; as, slow-gaited, slow-paced, slow-sighted, slow-winged, and the like. Slow coach, a slow person. See def.7, above. <zoology> Slow lemur, or Slow loris, an East Indian nocturnal lemurine animal (Nycticebus tardigradus) about the size of a small cat; so called from its slow and deliberate movements. It has very large round eyes and is without a tail. Called also bashful Billy. Slow match. See Match. Synonym: Dilatory, late, lingering, tardy, sluggish, dull, inactive. Slow, Tardy, Dilatory. Slow is the wider term, denoting either a want of rapid motion or inertness of intellect. Dilatory signifies a proneness to defer, a habit of delaying the performance of what we know must be done. Tardy denotes the habit of being behind hand; as, tardy in making up one's acounts. Origin: OE. Slow, slaw, AS. Slaw; akin to OS. Slu blunt, dull, D. Sleeuw, slee, sour, OHG. Slo blunt, dull, Icel. Slr, slr, Dan. Slov, Sw. Slo. Cf. Sloe, and Sloth. Source: Websters Dictionary (01 Mar 1998) |
| slow channel-blocking agent | calcium channel-blocking agent |
| slow combustion | See: decay. Spontaneous combustion, the ignition of a mass of material by heat developed within it by the oxidation of the substances composing it without external ignition. (05 Mar 2000) |
| slow fever | A continued fever of long duration. (05 Mar 2000) |
| slow muscle | <physiology> Striated muscle used for long term activity (e.g. Postural support). Depend therefore on oxidative metabolism and have many mitochondria and abundant myoglobin. (18 Nov 1997) |
| slow pyrolysis | Thermal conversion of biomass to fuel by slow heating to less than 450>C in the absence of oxygen. (05 Dec 1998) |