| simvastatin | <chemical> A derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase (hydroxymethylglutaryl CoA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic ldl receptors, it increases breakdown of ldl-cholesterol (lipoproteins, ldl cholesterol). Pharmacological action: anticholesteraemic agents, antilipaemic agents, hydroxymethylglutaryl-CoA reductase inhibitors. (12 Dec 1998) |
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| TAB vaccine | A suspension of killed typhoid and paratyphoid A and B bacilli. See: typhoid vaccine. Synonym: TAB vaccine. (05 Mar 2000) |