| GSR | galvanic skin response; generalized Shwartzman reaction; glutathione reductase |
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| GSSR | generalized Sanarelli-Shwartzman reaction |
| SGR | Sachs-Georgi reaction; Shwartzman generalized reaction; skin galvanic reflex; submandibular gland re... |
| SLR | Shwartzman local reaction; single lens reflex; straight leg raising |
| SSP | Sanarelli-Shwartzman phenomenon; subacute sclerosing panencephalitis; slice sensitivity profile; sub... |
| GSR | Generalized Shwartzman reaction |
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| shwartzman phenomenon | A two-stage reaction in which a first encounter with endotoxin produces intravascular fibrin thrombi whose clearance results in reticuloendothelial blockade which prevents the clearance of thrombi caused by a second encounter with endotoxin, resulting in tissue necrosis and/or haemorrhage. In pregnancy gram-negative septicaemia during delivery or abortion may serve as the first or provocative encounter. The phenomenon is non-immunologic and is known to occur only in rabbits and man. (12 Dec 1998) |
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| Shwartzman reaction | <investigation> Reaction that occurs when two injections of endotoxin are given to the same animal, particularly rabbits, 24h apart. In the local Shwartzman reaction the first injection is given intradermally, the second intravenously and a haemorrhagic reaction develops at the dermal site. If both injections are intravenous the result is a generalised Shwartzman reaction, often accompanied by disseminated intravascular coagulation. The reaction depends upon the response of platelets and neutrophils to endotoxin. (18 Nov 1997) |
| Shwartzman, Gregory | <person> Russian bacteriologist in U.S., 1896-1965. See: Shwartzman phenomenon, Shwartzman reaction, generalised Shwartzman phenomenon, Sanarelli-Shwartzman phenomenon. (05 Mar 2000) |
| generalised Shwartzman phenomenon | When both the primary injection of endotoxin-containing filtrate and the secondary injection are given intravenously 24 hours apart, the animal usually dies within 24 hours after the second inoculation; the characteristic lesions in the rabbit include widespread haemorrhages in the lung, liver, and other organs and bilateral cortical necrosis of the kidney. This reaction has no immunological basis. Synonym: Sanarelli phenomenon, Sanarelli-Shwartzman phenomenon. (05 Mar 2000) |
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| Sanarelli-Shwartzman phenomenon | When both the primary injection of endotoxin-containing filtrate and the secondary injection are given intravenously 24 hours apart, the animal usually dies within 24 hours after the second inoculation; the characteristic lesions in the rabbit include widespread haemorrhages in the lung, liver, and other organs and bilateral cortical necrosis of the kidney. This reaction has no immunological basis. Synonym: Sanarelli phenomenon, Sanarelli-Shwartzman phenomenon. (05 Mar 2000) |
Synonyms : Phenomenon, Shwartzman, Reaction, Shwartzman
| Shwartzman p. |
see under reaction.
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| Shwartzman r., generalized |
a generalized reaction following two intravenous injections of endotoxin separated by 24 hours; it is characterized by widespread hemorrhages, bilateral cortical necrosis of the kidneys, and a marked fall in leukocyte and platelet counts and usually results in death of the animal.
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| Shwartzman r., localized |
a localized cutaneous reaction consisting of vascular necrosis, petechial hemorrhages, and leukocyte infiltration that occurs at the site of an original subcutaneous injection of endotoxin approximately 24 hours after an intravenous injection of the same or another endotoxin given at a site other than the original injection site.
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| Shwartzman reaction (phenomenon) |
see under reaction.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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