| Schick | Bela, Austrian paediatrician in U.S., 1877-1967. See: Schick method, Schick test, Schick test toxin. (05 Mar 2000) |
|---|---|
| Schick method | A test for susceptibility to Corynebacterium diphtheriae toxin: 0.1 ml of Schick test toxin is injected into the skin of one forearm (test site) and the same quantity of the same, but heat-inactivated, material into the skin of the other forearm (control site); individuals with toxin-neutralizing antibodies either will have no reaction at either injection site (negative test) or may have a pseudoreaction due to antibodies for substances (antigens) in the test materials other than diphtheria toxin; individuals lacking toxin-neutralizing antibodies may have a positive reaction, which consists of an area of redness appearing 24 to 36 hours at the test site only and persisting for 4 to 5 days. Synonym: Schick method. (05 Mar 2000) |
| Schick test | A test for susceptibility to Corynebacterium diphtheriae toxin: 0.1 ml of Schick test toxin is injected into the skin of one forearm (test site) and the same quantity of the same, but heat-inactivated, material into the skin of the other forearm (control site); individuals with toxin-neutralizing antibodies either will have no reaction at either injection site (negative test) or may have a pseudoreaction due to antibodies for substances (antigens) in the test materials other than diphtheria toxin; individuals lacking toxin-neutralizing antibodies may have a positive reaction, which consists of an area of redness appearing 24 to 36 hours at the test site only and persisting for 4 to 5 days. Synonym: Schick method. (05 Mar 2000) |
| Schick test toxin | Corynebacterium diphtheriae toxin diluted so that the inoculated dose (0.1 or 0.2 ml) will contain 1/50 th of guinea pig minimal lethal dose. See: Schick test. Synonym: diagnostic diphtheria toxin. (05 Mar 2000) |