| nac | A naturally occurring substance that is metabolised into the amino acid cysteine. Cysteine is one of the three components of the major cellular antioxidant glutathione (see), and people with HIV have decreased levels of this compound. Clinical studies of oral and intravenously administered NAC are evaluating its usefulness in decreasing HIV activity. See: Oxidative Stress. (09 Oct 1997) |
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| gene products, rev | Trans-acting nuclear proteins whose functional expression are required for HIV viral replication. Specifically, the rev gene products are required for processing and translation of the HIV gag and env mRNAs, and thus rev regulates the expression of the viral structural proteins. Rev can also regulate viral regulatory proteins. A cis-acting antirepression sequence (car) in env, also known as the rev-responsive element (rre), is responsive to the rev gene product. Rev is short for regulator of virion. (12 Dec 1998) |
| genes, rev | DNA sequences that form the coding region for a protein that regulates the expression of the viral structural and regulatory proteins in human immunodeficiency virus (HIV). Rev is short for regulator of virion. (12 Dec 1998) |
| rev | <molecular biology> A regulatory protein produced by HIV within infected cells. Rev helps transport HIV RNA sequences (messenger RNA) out from the nucleus into the cells cytoplasm, where it directs construction of proteins for new virus particles. (11 Jan 1998) |