| diuretics, thiazide | Diuretics characterised as analogs of 1,2,4-benzothiadiazine-1,1-dioxide. All have a common mechanism of action and differ primarily in the dose required to produce a given effect. They act directly on the kidney to increase the excretion of sodium chloride and water and also increase excretion of potassium ions. (12 Dec 1998) |
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| rauwolfia alkaloids | <chemical> Alkaloids from rauwolfia serpentina benth and other species. The prototype is reserpine, which is a depleter of catecholamines and serotonin from the sympathetic postganglionic fibres and brain areas. They have been used in hypertension and psychoses despite their wide range of potentially adverse effects. Pharmacological action: adrenergic uptake inhibitors, antihypertensive agents, antipsychotic agents, sympatholytics. (12 Dec 1998) |
| rauwolfia | A genus of the apocynaceae or dogbane family of tropical trees and shrubs containing alkaloids. These alkaloids have been used as tranquillisers and antihypertensive agents. Reserpine is derived from r. Serpentina. (12 Dec 1998) |
| thiazide | <pharmacology> A group of medications that cause diuresis (loss of water through the kidney). They are frequently used to treat high blood pressure and congestive heart failure. Thiazides can cause low blood potassium levels if dietary potassium or (a potassium supplement) is not taken. Thiazides include hydrochlorothiazide, methyclothiazide, chlorthalidone, bendroflumethiazide, hydroflumethiazide, polythiazide, trichlormethiazide and chlorothiazide. (27 Sep 1997) |
| thiazide diabetes | Impaired carbohydrate metabolism associated with the use of thiazide diuretic drugs; severe manifestations are seen in persons having diabetes mellitus, but impairment is mild or absent in nondiabetic individuals. (05 Mar 2000) |
| mercurial diuretics | Diuretic drugs containing organic mercury (e.g., Mercuhydrin) which promote substantial salt and water loss through the kidney. Among the first potent diuretic agents used in congestive heart failure, but now obsolescent. (05 Mar 2000) |
| potassium sparing diuretics | Diuretic agents that, unlike most diuretics, retain potassium; examples are triamterene and amiloride. Often used together with diuretics that promote the loss of both sodium and potassium. Used in hypertension and in congestive heart failure. (05 Mar 2000) |
| diuretics | Agents that promote the excretion of urine through their effects on kidney function. (12 Dec 1998) |
| diuretics, mercurial | A group of organometallic compounds, now rarely used, that promote diuresis by inhibiting tubular reabsorption of sodium and chloride. (12 Dec 1998) |
| diuretics, osmotic | Diuretics that are filtered at the glomerulus and reabsorbed in the renal tubule only to a limited extent. They thus increase the amount of osmotically active solute in the urine and a corresponding increase in urine volume. These compounds also increase the osmolality of plasma, thereby increasing the diffusion of water from the intraocular and cerebrospinal fluids; they can be used for reducing the pressure and volume of these fluids. (12 Dec 1998) |
| diuretics, sulfamyl | Diuretics containing one or more sulfonamide groups. They are similar to the benzothiazide diuretics in their pharmacological actions, but differ chemically in the nature of the heterocyclic ring. (12 Dec 1998) |
| osmotic diuretics | Drugs, such as mannitol, which by their osmotic effects retain water during urine formation and thus dilute electrolytes in the urine, making resorption less efficient; they promote the elimination of water and electrolytes in the urine. (05 Mar 2000) |
| alkaloids | Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesised. (12 Dec 1998) |
| belladonna alkaloids | Alkaloids obtained from various plants, especially the deadly nightshade (atropa belladonna), variety acuminata; atropine, hyoscyamine and scopolamine are classical, specific antimuscarinic agents with many pharmacologic actions; used mainly as antispasmodics. (12 Dec 1998) |
| bisbenzylisoquinoline alkaloids | A group of alkaloids whose base structure is two fused isoquinoline rings e.g., curare alkaloids. (05 Mar 2000) |