| ras | <oncogene> One of a family of oncogenes, first identified as transforming genes of Harvey and Kirsten murine sarcoma viruses. (Name from rat sarcoma because Harvey virus, though a mouse virus, obtained its transforming gene during passage in a rat). Transforming protein coded is p21ras, a GTP-binding protein with GTPase activity, that resembles regulatory G-proteins. (18 Nov 1997) |
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| ras protein geranylgeranyltransferase | <enzyme> Mammalian enzyme transfers geranylgeranyl groups to a cysteine residue fourth from the c-terminal group of a p21 ras protein, prefers leucine at the cooh terminus; see also rhoa geranylgeranyltransferase and protein geranylgeranyltransferase Registry number: EC 2.5.1.- Synonym: geranylgeranyltransferase ras protein, ras protein gg transferase, ggtase I, caax geranylgeranyl transferase (26 Jun 1999) |
| ras proteins | Small GTP-binding proteins encoded by ras genes (genes, ras) that play a critical role in normal cellular growth, differentiation, and development, and have the potential for malignant transformation. Two of the major ras proteins include the normal cellular form, proto-oncogene protein p21(ras), and the malignant form, oncogene protein p21(ras). (12 Dec 1998) |
| rascaldom | State of being a rascal; rascality; domain of rascals; rascals, collectively. Source: Websters Dictionary (01 Mar 1998) |
| rascaless | A female rascal. Source: Websters Dictionary (01 Mar 1998) |
| rasceta | The transverse wrinkling on the anterior surface of the wrist. Origin: Mod. L. Raseta, fr. Ar. Rahah, palm of hand (05 Mar 2000) |
| rash | <dermatology> A skin eruption. (27 Sep 1997) |
| rasher | 1. A thin slice of bacon. 2. <zoology> A California rockfish (Sebastichthys miniatus). Origin: In sense 1, probably fr. Rash, a, as being hastily cooked. Source: Websters Dictionary (01 Mar 1998) |
| rasion | The subdivision of a crude drug by a rasp to prepare it for extraction. Origin: L. Rasio, a scraping, fr. Rado, pp. Rasus, to scrape, shave (05 Mar 2000) |
| raskolnik | One of the separatists or dissenters from the established or Greek church in Russia. Alternative forms: rascolnik. Origin: Russ. Rascolenik' schismatic, heretic. Source: Websters Dictionary (01 Mar 1998) |
| Rasmussen's aneurysm | Aneurysmal dilation of a branch of a pulmonary artery in a tuberculous cavity, rupture of which may cause serious haemoptysis. Aneurysm of the right ventricle or right ventricular outflow patch, aneurysm occurring after right ventriculostomy; the aneurysm may either be a false or a true aneurysm. (05 Mar 2000) |
| Rasmussen, Fritz | <person> Danish physician, 1834-1881. See: Rasmussen's aneurysm. (05 Mar 2000) |
| Rasmussen, Grant | <person> American neuroanatomist, *1904. See: bundle of Rasmussen. (05 Mar 2000) |
| rasores | <ornithology> An order of birds; the Gallinae. Formely, the word Rasores was used in a wider sense, so as to include other birds now widely separated in classification. Origin: NL, fr. L. Radere, rasum, to scratch. See Rase. Source: Websters Dictionary (01 Mar 1998) |
| rasorial | <ornithology> Of or pertaining to the Rasores, or gallinaceous birds, as the peacock, domestic fowl, patridge, and the like. Source: Websters Dictionary (01 Mar 1998) |
| p21(ras) farnesyl-protein transferase | <enzyme> Transfers the farnesyl moiety from farnesyl pyrophosphate to a cysteine in p21(ras) proteins; composed of an alpha and a beta subunit Registry number: EC 2.5.1.- Synonym: farnesyl-protein transferase p21(ras), ras p21 farnesyl-protein transferase, protein-cysteine farnesyltransferase, pc farnesyltransferase, protein farnesyltransferase, p21(ras) farnesyltransferase, farnesyl-protein transferase-alpha, farnesyl-protein transferase-beta, ft alpha, ft beta, caax farnesyltransferase, ftase enzyme (26 Jun 1999) |
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| genes, ras | Family of retrovirus-associated DNA sequences (ras) originally isolated from harvey (h-ras, ha-ras, rash) and kirsten (k-ras, ki-ras, rask) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both h-ras and k-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related n-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein. (12 Dec 1998) |
| proto-oncogene protein p21(ras) | Cellular protein encoded by the c-ras genes. The protein has GTPase activity and is involved in transmembrane signal transduction as a guanine nucleotide binding protein. Elevated levels of p21 c-ras have been associated with neoplasia. (12 Dec 1998) |
| h-ras | <oncogene> A point-mutated proto-oncogene that is found in melanoma and in carcinoma of colon, lung and pancreatic tissue. (10 Oct 1997) |
| oncogene protein p21(ras) | Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumours. (12 Dec 1998) |
| k-ras | <oncogene> A proto-oncogene that has point mutations and is associated with melanoma, thyroid carcinoma, and acute myelogenous and lymphoblastic leukaemia. (09 Oct 1997) |