| propranolol | <drug> Potent adrenergic antagonist acting at beta-1 and beta-2 adrenergic receptors. Pharmacologic action: Non-selective beta blockade (beta-1 and beta-2), reduces heart rate, myocardial contractility, and blood pressure, but also reduces myocardial oxygen demand. Uses: Atrial and ventricular tachyarrhythmias caused by catecholamines; hypertension, myocardial ischemia; hyperthyroidism, hypertrophic cardiomyopathy. Dose: 0.25 - 0.5 mg test dose, then 1 mg IV q min to desired effect Total dose should not exceed 0.1 mg/kg. Onset: 2 min Duration: 1 - 6 hr. Potential complications: Hypotension, bradycardia, worsened AV block, congestive heart failure and bronchospasm are unusual at low doses. Chemical name: 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride. (17 Mar 2000) |
|---|---|
| propranolol N-desisopropylase | <enzyme> Liver microsomal enzyme containing cytochrome p-448 Registry number: EC 1.- (26 Jun 1999) |