| colchicine | <drug> Alkaloid (400 D) isolated from the Autumn crocus (Colchicum autumnale) that blocks microtubule assembly by binding to the tubulin heterodimer (but not to tubulin). As a result of interfering with microtubule reassembly will block mitosis at metaphase. (18 Nov 1997) |
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| probenecid | <chemical> The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. Pharmacological action: renal agents, uricosuric agents. Chemical name: Benzoic acid, 4-((dipropylamino)sulfonyl)- (12 Dec 1998) |