| antigens, polyomavirus transforming | Polyomavirus antigens which cause infection and cellular transformation. The large t antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle t antigen for the transformation of primary cells. Small t antigen is necessary for the completion of the productive infection cycle. (12 Dec 1998) |
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| polyomavirus | <virology> A papovavirus (genus Polyomavirus, family Papovaviridae) which is a DNA tumour virus with very small genome. Polyoma was isolated from mice, in which it causes no obvious disease, but when injected at high titre into baby rodents, including mice, it causes tumours of a wide variety of histological types (hence polyoma). In vitro, infected mouse cells are permissive for virus replication and thus are killed, whilst hamster cells undergo abortive infection and at a low frequency become transformed. It is capable of producing parotid tumours in mice and sarcomas in hamsters as well as tumours in other laboratory animals. Synonym: mouse parotid tumour virus. (22 Sep 2002) |
| polyomavirus hominis 1 | <virology> A species of polyomavirus apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. The virus remains latent in the body throughout life and can be reactivated under certain circumstances. (12 Dec 1998) |
| polyomavirus hominis 2 | <virology> A species of polyomavirus, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials j.c. Gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus. (12 Dec 1998) |
| polyomavirus macacae | <virology> A species of polyomavirus isolated from rhesus monkey kidney tissue, which produces malignancy in human and newborn hamster kidney cell cultures and tumours on inoculation into newborn hamsters. (12 Dec 1998) |
| acinetobacter infections | Infections with bacteria of the genus acinetobacter. (12 Dec 1998) |
| actinobacillus infections | Infections with bacteria of the genus actinobacillus. (12 Dec 1998) |
| actinomycetales infections | Infections with bacteria of the order actinomycetales. (12 Dec 1998) |
| adenophorea infections | Infections with nematodes of the subclass adenophorea. (12 Dec 1998) |
| adenovirus infections, human | Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses. (12 Dec 1998) |
| aids-related opportunistic infections | Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include pneumocystis carinii pneumonia, kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with mycobacterium avium complex, microsporidium, and cytomegalovirus. (12 Dec 1998) |
| alphavirus infections | Virus diseases caused by members of the alphavirus genus of the family togaviridae. (12 Dec 1998) |
| anaplasmataceae infections | Infections with bacteria of the family anaplasmataceae. (12 Dec 1998) |
| arbovirus infections | Infections caused by arthropod-borne viruses, general or unspecified. (12 Dec 1998) |
| arenaviridae infections | Virus diseases caused by the arenaviridae. (12 Dec 1998) |