| Parvoviridae |
the parvoviruses: a family of DNA viruses having a nonenveloped virion 18–26 nm in diameter composed of 60 copies of the capsid protein with icosahedral symmetry. The genome consists of a single molecule of linear single-stranded DNA (MW 1.5–2.2 × 106, size 4–6 kb). Viruses contain 2–4 major polypeptides, depending on the species, and are resistant to heat, lipid solvents, deoxycholate, and nucleases but sensitive to formalin, β-propiolactone, hydroxylamine, oxidizing agents, and ultraviolet radiation. Replication and assembly occur in the nucleus and require S-phase cellular function in the host cell or the presence of helper virus. Host range is narrow and transmission may be vertical or by mechanical vectors. There are two subclasses: Densovirinae, comprising genera that infect invertebrates, and Parvovirinae, comprising genera that infect vertebrates.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
|
|---|