| parkinson disease | Progressive, degenerative disease of unknown aetiology characterised by rhythmic tremor of the limbs, stooped posture, slowness of voluntary movements, and masklike facial expression. Pathologically there is nerve cell loss in the melanin-containing cells in the brainstem and a corresponding reduction in dopamine levels in the corpus striatum. Lewy bodies are present in the substantia nigra and locus coeruleus. (12 Dec 1998) |
|---|---|
| parkinson disease, postencephalitic | A form of parkinson disease due to degeneration of the corpus striatum or substantia nigra, frequently occurring as a sequel of lethargic encephalitis. The early age of onset, the rapid progression of symptoms and signs of stabilization, and the presence of a variety of other neurological disorders (sociopathic behaviour, tics, spasms, oculogyric crises and other restricted motor disorders, breathing arrhythmias, hyperphagia, and bizarre movements, postures, and gaits) distinguish this disease from the one described by parkinson. (12 Dec 1998) |
| parkinson disease, symptomatic | Symptoms of parkinson disease induced by drugs, or following cerebral arteriosclerosis, brain tumour, or other central nervous system disorders except encephalitis, which is parkinson disease, postencephalitic. (12 Dec 1998) |
| Parkinson's disease | <neurology> A progressive, neurological disease first described in 1817 by James Parkinson. The pathology is not completely understood, but there appears to be consistent changes in the melanin-containing nerve cells in the brainstem (substantia nigra, locus coeruleus), where there are varying degrees of nerve cell loss with reactive gliosis along with eosinophilic intracytoplasmic inclusions (Lewy bodies). Biochemical studies have shown below normal levels of dopamine in the caudate nucleus and putamen. Symptoms include shuffling gait, stooped posture, resting tremor, speech impediments, movement difficulties and an eventual slowing of mental processes and dementia. (27 Sep 1997) |
| Parkinson's facies | The expressionless or masklike facies characteristic of parkinsonism. Synonym: masklike face. (05 Mar 2000) |
| Parkinson, James | <person> This English physician is chiefly remembered for his 66-page "Essay on the Shaking Palsy" (first edition is valued at |
| Parkinson, Sir John | <person> British cardiologist, *1885. See: Wolff-Parkinson-White syndrome. (05 Mar 2000) |
| parkinsonian | Relating to or the suffering from parkinsonism. (05 Mar 2000) |
| parkinsonism | <neurology> A group of neurological disorders characterised by hypokinesia, tremor and muscular rigidity. (18 Nov 1997) |
| wolff-parkinson-white syndrome | <syndrome> A form of pre-excitation characterised by a short pr interval and a long qrs interval with a delta wave. (12 Dec 1998) |
|---|---|
| Wolf Parkinson White syndrome | <cardiology, syndrome> Abnormal cardiac conduction that occurs by way of an accessory pathway between the atria and the ventricles. Baseline ECG will typically show a short P-R interval and a slurred upstroke of the QRS (delta wave). Tachyarrhythmias are common. (27 Sep 1997) |
| disease, parkinson's | An abnormal condition of the nervous system caused by degeneration of an area of the brain called the basal ganglia. The disease results in rigidity of the muscles, slow body movement and tremor. Parkinson's disease is also called paralysis agitans and shaking palsy. (12 Dec 1998) |
| James Parkinson | <person> This English physician is chiefly remembered for his 66-page "Essay on the Shaking Palsy" (first edition is valued at |