| Paramyxoviridae |
the paramyxoviruses: a family of RNA viruses having a pleomorphic, usually roughly spherical but occasionally filamentous virion 150–300 nm in diameter, consisting of a lipid bilayer membrane with large peplomers surrounding a helical nucleocapsid. The genome consists of a single molecule of negative-sense single-stranded RNA (MW 5–7 × 106, size 16 kb). Viruses contain six to ten major polypeptides, including a transcriptase, and are sensitive to lipid solvents, detergents, disinfectants, and extremes of pH; thermostability varies according to genus. Replication occurs in the cytoplasm and assembly is by budding through the plasma membrane. Host range is generally narrow in nature but broad in cultured cells, and transmission is horizontal, chiefly airborne. There are two subfamilies, Paramyxovirinae and Pneumovirinae.
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