| Orthomyxoviridae | <organism, virology> Class V viruses. The genome consists of a single negative strand of RNA that is present as several separate segments each of which acts as a template for a single mRNA. The nucleocapsid is helical and has a viral specific RNA polymerase for the synthesis of the mRNAs. They leave cells by budding out of the plasma membrane and are thus enveloped. They usually have two classes of spike protein in the envelope. One has haemagglutinin activity and the other acts as a neuraminidase and both are important in the invasion of cells by the virus. The major viruses of this group are the influenza viruses. (18 Nov 1997) |
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| orthomyxoviridae infections | Virus diseases caused by the orthomyxoviridae. (12 Dec 1998) |
Synonyms : Orthomyxoviruses, Influenza Virus, Myxovirus, Orthomyxovirus
Synonyms : Infections, Orthomyxoviridae, Infections, Orthomyxovirus, Infection, Orthomyxoviridae, Infection, Orthomyxovirus, Orthomyxoviridae Infection, Orthomyxovirus Infection
| Orthomyxoviridae |
the influenzaviruses: a family of RNA viruses having a pleomorphic virion that may be roughly spherical and 80120 nm in diameter or filamentous and up to several microns long, consisting of a lipid bilayer envelope with large peplomers, surrounding a helical nucleocapsid. The genome consists of seven (influenza C virus) or eight (influenza A virus and influenza B virus) molecules of linear negative-sense single-stranded RNA (total MW approximately 5 × 106, total size 10.013.6 kb). Viruses contain seven to nine major polypeptides, including a transcriptase and a neuramidase, and are sensitive to lipid solvents, radiation, and disinfectants. Replication occurs in the nucleus and cytoplasm, and assembly is by budding on the plasma membrane. Genera include Influenzavirus A, Influenzavirus B, Influenzavirus C, and the Thogoto-like viruses.
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