| ambident ligand | <chemistry> A ligand that can donate electrons through two or more atoms on their molecule. (05 Feb 1998) |
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| cyanocobalamin beta-ligand transferase | <enzyme> Cytosolic enzyme utilizing fad, NADPH and reduced glutathione; forms glutathionylcobalamin from cyanocobalamin Registry number: EC 2.5.1.- Synonym: ccbl transferase (26 Jun 1999) |
| ELAM-1 ligand fucosyltransferase | <enzyme> Directs the expression of an elam-1 ligand; an alpha(1,3) fucosyltransferase Registry number: EC 2.4.1.- Synonym: elft protein, elft gene product (26 Jun 1999) |
| ligand | <chemistry, immunology> Any molecule that binds to another, in normal usage a soluble molecule such as a hormone or neurotransmitter, that binds to a receptor. The decision as to which is the ligand and which the receptor is often a little arbitrary when the broader sense of receptor is used (where there is no implication of transduction of signal). In these cases it is probably a good rule to consider the ligand to be the smaller of the two thus in a lectin sugar interaction, the sugar would be the ligand (even though it is attached to a much larger molecule, recognition is of the saccharide). (18 Nov 1997) |
| ligand binding site | The site on a protein's surface that binds a ligand; equivalent to the active site if the ligand is the substrate of an enzyme. (05 Mar 2000) |
| ligand-gated channel | A class of ion channel's whose ionic permeability is regulated by cell membrane receptors that respond to specific extracellular chemical signals. (05 Mar 2000) |
| ligand gated ion channel | A transmembrane ion channel whose permeability is increased by the binding of a specific ligand, typically a neurotransmitter at a chemical synapse. The permeability change is often drastic, such channels let through effectively no ions when shut, but allow passage at up to 10exp7 ions sexp 1 when a ligand is bound. Recently, the receptors for both acetylcholine and GABA have been found to share considerable sequence homology, implying that there may be a family of structurally related ligand gated ion channels. (18 Nov 1997) |
| ligand induced endocytosis | The formation of coated pits and then coated vesicles as a consequence of the interaction of ligand with receptors, which then interact with clathrin and associated proteins (coatomers) on the cytoplasmic face of the plasma membrane and come together to form a pit. Not all coated vesicle uptake of receptors requires receptor occupancy. (18 Nov 1997) |