| NF | <abbreviation> National Formulary. (05 Mar 2000) |
|---|---|
| NF _kappa_B | A transcription factor (originally found to switch on transcription of genes for the kappa class of immunoglobulins in B lymphocytes). It is involved in activating the transcription of more than 20 genes in a variety of cells and tissues. NF _B is found in the cytoplasm in an inactive form, bound to the protein I_B. A variety of stimuli, such as tumour necrosis factor, phorbol esters and bacterial lipopolysaccharide activate it, by releasing it from I_B, allowing it to enter the nucleus and bind to DNA. It has two subunits p50 and p65 that bind DNA as a heterodimer. The dimerisation and DNA binding activity are located in N terminal regions of 300 amino acid that are similar to regions in the Rel and dorsal transcription factors. (18 Nov 1997) |
| nf-kappa b | Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in lymphoid cells. In B-lymphocytes nf-kappa b binds to the immunoglobulin kappa light chain enhancer and in T-lymphocytes it has been shown to bind to the enhancers in virally infected cells including HIV. (12 Dec 1998) |
| NF-kappa B kinase | <enzyme> Activates DNA-binding activity of nfkb by directly phosphorylating its p65 and p50 subunits; does not phosphorylate ikb; may have a central role in mediating various signals to nfkb; mw 43 kD; amino acid sequence given in second source Registry number: EC 2.7.10.- Synonym: nuclear factor kappa b kinase, nfkb kinase, nik protein, nik gene product, nf-kappab-inducing kinase (26 Jun 1999) |