| end-stage renal disease | <nephrology> A patient with inadequate renal function to support life. Individuals with end-stage disease must rely in kidney dialysis or peritoneal dialysis to survive. End-stage renal disease may be caused by a number of problems including diabetes, sickle cell disease, hypertension and congenital renal disease (polycystic kidney disease). (27 Sep 1997) |
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| end stage | The late, fully developed phase of a disease; e.g., in end-stage renal disease, a shrunken and scarred kidney that may result from a variety of chronic diseases that have become indistinguishable in their effect on the kidney. (05 Mar 2000) |
| end-to-end bite | An occlusion in which the anterior teeth of both jaws meet along their incisal edges when the teeth are in centric occlusion. Synonym: edge-to-edge bite, end-to-end bite, end-to-end occlusion. (05 Mar 2000) |
| end-to-end occlusion | An occlusion in which the anterior teeth of both jaws meet along their incisal edges when the teeth are in centric occlusion. Synonym: edge-to-edge bite, end-to-end bite, end-to-end occlusion. (05 Mar 2000) |
| middle stage HIV disease | <disease> This refers to an HIV infection that is characterised by signs and symptoms of HIV that are not life-threatening. Examples include oral thrush, gingivitis, seborrheic dermatitis, molluscum contangiosum, fevers, fatigue, lymph node swelling, malaise and weight loss. This stage can be a signal for the conversion from asymptomatic HIV disease to HIV disease (moe pronouced symptoms include joint pains). AIDS is diagnosed after HIV disease has started to manifest life-threatening oppotunistic infections (for example pneumocystis, cryptosporidium, toxoplasmosis, etc). (27 Sep 1997) |
| alcoholic liver disease | <gastroenterology> Alcoholic cirrhosis is a condition of irreversible liver disease due to the chronic inflammatory and toxic effects of ethanol on the liver. In cirrhosis, the liver cells are replaced by fibrous scar tissue. Fibrosis leads to the development of portal hypertension. The development of cirrhosis is directly related to the duration and quantity of alcohol consumption. The manifestations of cirrhosis are related to the liver's inability to not adequately remove waste products from the bloodstream and the effects of portal hypertension. (15 Nov 1997) |
| veno-occlusive disease of the liver | Obliterating endophlebitis of small hepatic vein radicles, described in Jamaican children, associated with ingestion of toxic plant substances in bush tea; causes ascites, which may progress to cirrhosis. (05 Mar 2000) |
| chronic active liver disease | Any of several types of hepatitis persisting for more than six months, often progressing to cirrhosis. Synonym: chronic active liver disease. (05 Mar 2000) |
| polycystic liver disease | Gradual cystic dilation of intralobular bile ducts (Meyenburg's complexes) that fail to involute in embryologic development of the liver; frequently associated with bilateral congenital polycystic kidneys and occasionally with cystic involvement of the pancreas, lungs, and other organs. Synonym: polycystic liver disease. (05 Mar 2000) |
| Adair-Koshland-Nemethy-Filmer model | <biochemistry, chemistry> A model to explain the allosteric form of cooperativity; in this model, in the absence of ligands, the protein exists in only one conformation; upon binding, the ligand induces a conformational change that may be transmitted to other subunits. Synonym: Adair-Koshland-Nemethy-Filmer model, induced fit model. (05 Mar 2000) |
| additive model | A model in which the combined effect of several factors is the sum of the effects that would be produced by each of the factors in the absence of the others. (05 Mar 2000) |
| age-structured model | <epidemiology> A mathematical model which take into consideration the division of the host population into different age classes. Such models can used to consider the consequences of such factors as age-dependent infection, morbidity or mortality rates or of age-specific vaccination schedules. (05 Dec 1998) |
| animal model | Study in a population of laboratory animals that uses conditions of animals analogous to conditions of humans to simulate processes comparable to those that occur in human populations. (05 Mar 2000) |
| Bingham model | A model representing the flow behaviour of a Bingham plastic, in the idealised case. (05 Mar 2000) |
| biomedical model | A conceptual model of illness that excludes psychological and social factors and includes only biological factors in an attempt to understand a person's medical illness or disorder. (05 Mar 2000) |