| metyrapone | <chemical> Chemical name: 1-Propanone, 2-methyl-1,2-di-3-pyridinyl- (12 Dec 1998) |
|---|---|
| metyrapone reductase | <enzyme> From mouse liver microsomes, belongs to the family of carbonyl reductases; can use NADH or NADPH as co-substrates Registry number: EC 1.1.1.- (26 Jun 1999) |
| metyrapone test | <endocrinology, investigation> This test measures the ability of the pituitary gland to secrete ACTH in response to a low serum cortisol level. Under normal conditions a low serum cortisol level should stimulate the pituitary to produce ACTH, which stimulates the adrenal glands to produce more cortisol. This test is performed by injecting metyrapone into the bloodstream and then measuring cortisol levels over a period of time. Metyrapone is a substance which inhibits an enzyme (steroid 11-beta hydroxylase) involved in the synthesis of cortisol. This enzyme normally converts 11-deoxycortisol to cortisol. When the enzyme is inhibited, 11-deoxycortisol levels will increase in the blood and urine and cortisol levels will go down. This test is useful in differentiating the different forms of Cushing's syndrome: adrenal hyperplasia versus primary adrenal tumour. Those with an adrenal tumour (or carcinoma) generally have no response to metyrapone injection, since the dose is insufficient to inhibit cortisol synthesis. (27 Sep 1997) |
| administration, oral | The giving of drugs, chemicals, or other substances by mouth. (12 Dec 1998) |
| cancer, oral | Cancer of the mouth area. A sore in the mouth that does not heal can be a warning sign of oral cancer. A biopsy is the only to know whether as abnormal area in the oral cavity is cancer. Oral cancer is caused by tobacco (smoking and chewing) and alcohol use. Surgery to remove the tumour in the mouth is the usual treatment for patients with oral cancer. (12 Dec 1998) |
| candidiasis, oral | Infection of the mucous membranes of the mouth by a fungus of the genus candida. (12 Dec 1998) |
| canine oral papilloma | Warts affecting mucous membranes of young dogs; caused by a papillomavirus. (05 Mar 2000) |
| magnesia and alumina oral suspension | A mixture of magnesium hydroxide and variable amounts of aluminum oxide; used as an antacid. (05 Mar 2000) |
| pathology, oral | A dental specialty concerned with pathology of the oral cavity. (12 Dec 1998) |
| pharyngo-oral | Relating to the pharynx and the mouth; oropharyngeal. Origin: pharyngo-+ L. Os (or-), mouth (05 Mar 2000) |
| combination oral contraceptive | A mixture of a steroid having progestational activity and an oestrogen. (05 Mar 2000) |
| contraceptives, oral | Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally oestrogen or progesterone or both. (12 Dec 1998) |
| contraceptives, oral, combined | Fixed drug combinations administered orally for contraceptive purposes. (12 Dec 1998) |
| contraceptives, oral, hormonal | Oral contraceptives which owe their effectiveness to hormonal preparations. (12 Dec 1998) |
| contraceptives, oral, sequential | Drugs administered orally and sequentially for contraceptive purposes. (12 Dec 1998) |