| Marfan, Antoine Bernard-Jean | <person> French paediatrician, 1858-1942. See: Marfan's disease, Marfan's law, Marfan's syndrome. (05 Mar 2000) |
|---|---|
| Marfan's disease | <syndrome> A hereditary condition of the connective tissue. Symptoms and signs include tall lean body type, irregular or unsteady gait, long extremities (including fingers and toes), abnormal joint flexibility, flat feet, stooped shoulders, dislocation of the optic lens and aneurysms of the aorta. Affects 1 in 50,000 people. Probably a collagen fibril assembly disorder since it can be mimicked in mice by aminonitriles that interfere with crosslinking. Inheritance: autosomal dominant. (06 Oct 1997) |
| Marfan's law | The healing of localised tuberculosis protects against subsequent development of pulmonary tuberculosis. (05 Mar 2000) |
| Marfan's syndrome | <syndrome> A hereditary condition of the connective tissue. Symptoms and signs include tall lean body type, irregular or unsteady gait, long extremities (including fingers and toes), abnormal joint flexibility, flat feet, stooped shoulders, dislocation of the optic lens and aneurysms of the aorta. Affects 1 in 50,000 people. Probably a collagen fibril assembly disorder since it can be mimicked in mice by aminonitriles that interfere with crosslinking. Inheritance: autosomal dominant. (06 Oct 1997) |
| marfan syndrome | <radiology> Connective-tissue disorder: autosomal dominant, 15% sporadic, cardiovascular system (probable cause of death in 93%), aortic aneurysm (mostly ascending), dilatation of aortic sinuses, aortic dissection, coarctation, musculoskeletal system, tall stature, long limbs, arachnodactyly, lax joints, scoliosis (60%) / kyphosis / pectus, eye, lens subluxation Cf: homocystinuria More info: Marfan syndrome (12 Dec 1998) |
| syndrome, marfan | Inherited disorder with long fingers and toes, dislocation of the lens, and aortic wall weakness and aneurysm. (it has been suggested that abraham lincoln had marfan syndrome.) (12 Dec 1998) |
| Aaron's sign | <clinical sign> In acute appendicitis, a referred pain or feeling of distress in the epigastrium or precordial region on continuous firm pressure over McBurney's point. (05 Mar 2000) |
| Abadie's sign of tabes dorsalis | Insensibility to pressure over the tendo achillis. (05 Mar 2000) |
| Abrahams' sign | <clinical sign> An obsolete sign: Rales and other adventitious sounds, changes in the respiratory murmurs, and increase in the whispered sound can be heard on auscultation over the acromial end of the clavicle some time before they become audible at the apex; heard primarily in pulmonary tuberculosis affecting the apical portion of the lung, a dull-flat note, i.e., one between the normal dullness at the right apex and absolute flatness, heard on percussion in that region, indicating progress from incipient to advanced tuberculosis. (05 Mar 2000) |
| accessory sign | <clinical sign> A finding frequently but not consistently present in a disease. Synonym: assident sign. (05 Mar 2000) |
| Allis' sign | <clinical sign> In fracture of the neck of the femur, the trochanter rides up, relaxing the fascia lata, so that the finger can be sunk deeply between the great trochanter and the iliac crest. (05 Mar 2000) |
| Amoss' sign | <clinical sign> In painful flexion of the spine, it is necessary to support a sitting position by extending the arms behind the torso with the weight placed on the hands. (05 Mar 2000) |
| Anghelescu's sign | <clinical sign> In vertebral tuberculosis, painful or impossible flexion of the spine when the patient attempts to rest weight on the heels and occiput. (05 Mar 2000) |
| antecedent sign | <clinical sign> A sign that appears during the prodrome of a disease. Synonym: antecedent sign. (05 Mar 2000) |
| assident sign | <clinical sign> A finding frequently but not consistently present in a disease. Synonym: assident sign. (05 Mar 2000) |