| Machado-Guerreiro test | A complement-fixation test for infection with Trypanosoma cruzi. (05 Mar 2000) |
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| Machado-Joseph | A rare form of hereditary ataxia, characterised by onset in early adult life of progressive, spinocerebellar and extrapyramidal disease with external ophthalmoplegia, rigidity dystonia symptoms, and, often, peripheral amyotrophy; found predominantly in people of Azorean ancestry; autosomal dominant inheritance. Synonym: Azorean disease, Portuguese-Azorean disease. Origin: Surnames of two families studied in major descriptions of the disease. (05 Mar 2000) |
| machado-joseph disease | A progressive degenerative disease of the central nervous system occurring in portuguese-azorean families, having a variety of forms and inherited as an autosomal dominant trait. There are four major types: type I: with pyramidal and extrapyramidal deficits; type II: with cerebellar, pyramidal and extrapyramidal deficits; type III: with cerebellar deficits and distal sensorimotor neuropathy; type IV: with parkinsonism and distal sensory neuropathy. It was originally reported in two portuguese-azorean families in massachusettes (machado), then in another portuguese family (thomas), and later in a third family in california (joseph, who settled there in 1845). It has been reported also in japanese families. (12 Dec 1998) |