| genes, mdr | Genes responsible for multidrug resistance resulting from their overexpression in mammalian cells. Mammalian p-glycoproteins are encoded by small mdr gene familes. The human multidrug resistance 1 (mdr1) gene responds to environmental stress including various anticancer agents. It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents. (biochem biophys res commun 1994;199(3):1428-35; cancer res 1994:54(6):1536-41) (12 Dec 1998) |
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