| drug-drug interaction | The effects that occur when two or more drugs are used together. Such effects include changes of absorption in the digestive tract, changes in rate of the drugs' breakdown in the liver, new or enhanced side effects and changes in the drugs' activity. (09 Oct 1997) |
|---|---|
| pigmented purpuric lichenoid dermatosis | An eruption comprised of lichenoid papules variously pigmented from the haemosiderin of the associated purpura; found on the legs, usually in men over 40 years of age. Synonym: Gougerot and Blum disease. (05 Mar 2000) |
| exudative discoid and lichenoid dermatitis | Disease resembling an exudative form of nummular eczema described in Jewish males with oval lesions on the penis, trunk, and face. Synonym: exudative discoid and lichenoid dermatitis, Sulzberger-Garbe syndrome. (05 Mar 2000) |
| lichenoid | 1. Resembling lichen. 2. Accentuation of normal skin markings observed in cases of chronic eczema. 3. Microscopically resembling lichen planus. (05 Mar 2000) |
| lichenoid amyloidosis | Localised cutaneous amyloidosis with pruritic brownish-red papules, most commonly on the lower legs, due to amyloid infiltration of the papillary dermis. Synonym: amyloidosis cutis, lichen amyloidosis. Origin: G. Leichen, lichen, a lichen-like eruption + eidos, resemblance (05 Mar 2000) |
| lichenoid dermatosis | Any chronic skin eruption, characterised clinically by induration and thickening of the skin with accentuation of skin markings, and microscopically by a band-like lymphocytic infiltration of the papillary dermis. (05 Mar 2000) |
| lichenoid eczema | Thickening of skin with accentuated skin lines in eczema. Synonym: chronic eczema, eczema hypertrophicum. (05 Mar 2000) |
| lichenoid eruptions | Conditions in which there is histological damage to the lower epidermis along with a grouped chronic inflammatory infiltrate in the papillary dermis disturbing the interface between the epidermis and dermis. Lichen planus is the prototype of all lichenoid eruptions. (12 Dec 1998) |
| lichenoid keratosis | A solitary benign papule or plaque, with microscopic features resembling lichen planus, occurring on sun-exposed or unexposed skin. Synonym: lichen planus-like keratosis. (05 Mar 2000) |
| adverse drug reaction reporting systems | Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions. (12 Dec 1998) |
| abnormalities, drug-induced | Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. (12 Dec 1998) |
| activity, drug | A measure of the physiological response a drug produces in the body. A less active drug produces less response (and visa versa). (12 Dec 1998) |
| addictive drug | Any drug that creates a certain degree of euphoria and has a strong potential for addiction. (05 Mar 2000) |
| akathisia, drug-induced | Motor restlessness with sensations of quivering and an urge to move about constantly resulting from the use of certain drugs, such as neuroleptic drugs, which affect the extrapyramidal region of the brain. This differs from dyskinesia, drug-induced in that long-term antipsychotic drug exposure is significantly correlated with the increased prevalence of akathisia while there is no such correlation with dyskinesia. The primary observable distinction between tardive akathisia and dyskinesia appears to be in the repetitive, stereotypy of the dyskinesic movements (lip smacking, for example), while akathisia is associated with anxiety, restlessness, and agitation (psychomotor agitation). (12 Dec 1998) |
| antineoplastic drug | A drug that stops or slows the maturation and spread of tumour cells (benign or malignant). (09 Oct 1997) |