| Landsteiner | Karl, Austrian-U.S. Pathologist and Nobel laureate, 1868-1943. See: Landsteiner-Donath test, Donath-Landsteiner cold autoantibody, Donath-Landsteiner phenomenon. (05 Mar 2000) |
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| Landsteiner, Karl | <person> This native of Vienna in 1900 discovered iso-agglutinins in human blood and then showed that blood had specific groups, which was responsible for the safety of giving blood transfusions. With Alexander Weiner, he discovered the Rh factor in human blood. Along with Poppen he proved that poliomyelitis could be transmitted to subhuman primates by intraspinal injection. From 1892 to 1943 Landsteiner published 346 scientific articles. In 1930, he became a winner of the Nobel Prize. Lived: 1868-1943. (15 Nov 1997) |
| Landsteiner-Donath test | The haemolysis which results in a sample of blood of a subject of paroxysmal haemoglobinuria when the sample is cooled to around 5캜 and then warmed again. (05 Mar 2000) |
| Donath-landsteiner | <investigation> A serologic blood test used to detect antibody in serum in cases of suspected paroxysmal cold haemoglobinuria. The antibody is directed toward the P-antigen complex which is located on the surface of red blood cells. In some way, cold temperatures trigger the antibody to bind to this site. (15 Nov 1997) |
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| Donath-Landsteiner cold autoantibody | An autoantibody of the IgG class responsible for paroxysmal cold haemoglobinuria; it is adsorbed to red cells only at temperatures of 20캜 or lower, causing the red cells to lyse in the presence of complement at higher temperatures; it has only slight agglutinating properties in spite of its marked lytic activity, and has a specificity within the blood group P; it is also occasionally present for short periods of time following measles and other infections, and formerly was frequently associated with syphilis. Synonym: cold haemolysin. (05 Mar 2000) |
| Donath-Landsteiner phenomenon | The haemolysis which results in a sample of blood of a subject of paroxysmal haemoglobinuria when the sample is cooled to around 5캜 and then warmed again. (05 Mar 2000) |
| Karl Landsteiner | <person> This native of Vienna in 1900 discovered iso-agglutinins in human blood and then showed that blood had specific groups, which was responsible for the safety of giving blood transfusions. With Alexander Weiner, he discovered the Rh factor in human blood. Along with Poppen he proved that poliomyelitis could be transmitted to subhuman primates by intraspinal injection. From 1892 to 1943 Landsteiner published 346 scientific articles. In 1930, he became a winner of the Nobel Prize. Lived: 1868-1943. (15 Nov 1997) |