| mice, inbred mrl lpr | A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the mrl/lpr is a useful model to study behavioural and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents. (12 Dec 1998) |
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