| LEM | a spacecraft that carries astronauts from the command module to the surface of the moon and back |
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| LEM | tropical American cacti usually tall and branching with stout spines and funnel-shaped flowers and globular or ovoid often edible fruit |
| LEM | tall treelike Mexican cactus with edible red fruit |
| LEM | Belgian cosmologist who proposed the big-bang theory of the origin of the universe (1894-1966) |
| LEM | hybrid between mandarin orange and lemon having very acid fruit with orange peel |
| LEM | the head of an annotation or gloss |
| LEM | a subsidiary proposition that is assumed to be true in order to prove another proposition |
| LEM | the lower and stouter of the two glumes immediately enclosing the floret in most Gramineae |
| LEM | any of various short-tailed furry-footed rodents of circumpolar distribution |
| LEM | United States film actor (born in 1925) |
| LEM | lemmings |
| LEM | notable for mass migrations even into the sea where many drown |