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POU domain <molecular biology> A conserved protein domain of around 150 amino acids, composed of a 20 amino acid homeobox domain and a larger POU specific domain and so is the target of some transcription factors.
Named POU (Pit Oct Unc) after 3 such proteins: Pit 1 regulates expression of certain pituitary genes, Oct 1 and 2, that bind an octamer sequence in the promoters of histone H2A and some immunoglobulin genes and Unc 86, involved in nematode sensory neuron development.
(31 Dec 1997)
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