| ILE | a region of north central France in the Paris Basin |
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| ILE | island in Paris on the Seine |
| ILE | branch of the superior mesenteric artery that supplies the ileum |
| ILE | inflammation of the ileum |
| ILE | valve between the ileum of the small intestine and the cecum of the large intestine |
| ILE | an artery that originates from the superior mesenteric artery and supplies the terminal part of the ileum and the cecum and the vermiform appendix and the ascending colon |
| ILE | a vein that drains the end of the ileum and the appendix and the cecum and the lower part of the ascending colon |
| ILE | surgical procedure that creates an opening from the ileum through the abdominal wall to function as an anus |
| ILE | three main islands and numerous islets in the Indian Ocean between Mozambique and Madagascar |
| ILE | a group of volcanic islands in the south central Pacific |
| ILE | the part of the small intestine between the jejunum and the cecum |
| ILE | blockage of the intestine (especially the ileum) that prevents the contents of the intestine from passing to the lower bowel |