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IL-1 Interleukin-1
IL-1 interleukin 1
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IL-1 Interleukin 1 alpha
IL-1 Interleukin 1 beta
IL-1 alpha Interleukin -1 alpha
IL-1 beta interlukin-1 beta
IL-1 RI IL-1 receptor
IL-10 Interleukin 10
IL-11 Interleukin 11
IL-12R IL-12 receptor
IL-13 Interleukin 13
IL-15 Interleukin 15
CancerWEB ¿µ¿µ ÀÇÇлçÀü ¸ÂÃã °Ë»ö °á°ú : 8 ÆäÀÌÁö: 1
IL-1 <cytokine> A soluble protein (17 kD: 152 amino acids) secreted by monocytes, macrophages or accessory cells involved in the activation of both T-lymphocytes and B lymphocytes and potentiates their response to antigens or mitogens.
Its biological effects include the ability to replace macrophage requirements for T-cell activation, as well as affecting a wide range of other cell types. at least two IL-1 genes are active and alpha and beta forms of IL-1 are recognised.
It is released early in an immune system response by monocytes and macrophages. It stimulates T-cell proliferation and protein synthesis. Another effect of IL-1 is that it causes fever.
See: catabolin, endogenous pyrogen.
Acronym: IL-1
(12 Dec 1998)
IL-10 <cytokine> A factor produced by Th2 helper T-cells, some B-cells and LPS activated monocytes.
It is a coregulator of mast cell growth. It is produced by T-cells and B-cells and shows extensive homology with the Epstein-Barr virus bcrfi gene.
Chemical name: Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced)
Acronym: IL-10
(12 Dec 1998)
IL-11 <cytokine> Pleiotropic cytokine originally isolated from primate bone marrow stromal cell line that has the ability to modulate antigen-specific antibody responses, potentiate megakaryocytes, and regulate bone marrow adipogenesis.
Stimulates T-cell dependent B-cell maturation, megakaryopoiesis, various stages of myeloid differentiation. Receptor probably a tyrosine kinase.
Acronym: IL-11
(12 Dec 1998)
IL-12 <cytokine> A 75 kD heterodimeric cytokine composed of disulfide-bonded 40 kD and 35 kD subunits that was originally identified by its ability to induce cytotoxic effector cells in synergy with less than optimal concentrations of interleukin-2.
It is released by macrophages in response to infection and promotes the activation of cell-mediated immunity. Specifically, IL-12 triggers the maturation of Thl CD4 cells, specific cytotoxic T-lymphocyte responses and an increase in the activity of NK cells and consequently, it is the initiator of cell-mediated immunity.
It enhances the lytic activity of NK cells, induces interferon production, stimulates the proliferation of activated T-cells and NK cells. Is secreted by human B lymphoblastoid cells (NC 37). May play a role in controlling immunoglobulin isotype selection as it also inhibits IgE synthesis (even in the presence of anti-IFN monoclonal antibody) and as a growth factor for activated CD4+ and CD8+ T-cells independently of interleukin-2, and for CD56+ NK cells but not resting peripheral blood mononuclear cells or resting or activated tonsillar B-cells.
It is likely that interleukin 12 has a major role in protective immunity against viruses and is under study as an immunotherapy in HIV infection.
Formerly referred to as cytotoxic lymphocyte maturation factor.
Acronym: IL-12
(12 Dec 1998)
IL-13 <cytokine> A T-lymphocyte-derived cytokine that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-lymphocytes.
It appears to play a role in regulating inflammatory and immune responses and has anti-inflammatory activity.
Produced by activated T-cells, inhibits IL-6 production by monocytes and also the production of other pro inflammatory cytokines such as TNF, IL-1, IL-8. Stimulates B-cells. Gene is located in cluster of genes on human chromosome 5q that also has IL-4 gene.
Acronym: IL-13
(12 Dec 1998)
IL-14 Cytokine that induces B-cell proliferation, inhibits immunoglobulin secretion, and selectively expands certain B-cell subpopulations.
Acronym: IL-14
(12 Dec 1998)
IL-15 Cytokine that stimulates the proliferation of T-lymphocytes and shares biological activities with il-2. Il-15 also can induce b-lymphocyte proliferation and differentiation.
Acronym: IL-15
(12 Dec 1998)
IL-16 Cytokine produced by activated T-lymphocytes that stimulates the migration of CD4-positive lymphocytes and monocytes. It has been reported to suppress HIV replication.
(12 Dec 1998)
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TNF-IL1-activated protein kinase <enzyme> Phosphorylates beta casein in vitro; not the same as casein kinase 1 and casein kinase 2; not activated by mitogens, celllular stresses or any other cytokines than il1 and tnf
Registry number: EC 2.7.1.-
Synonym: tip kinase, beta casein kinase
(26 Jun 1999)
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IL-1 Interleukin-1 (IL-1) is secreted by the macrophages, monocytes and dendritic cells. It is an important part of the inflammatory response. It increases the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes. It also re-sets the hypothalamus thermoregulatory center, leading to an increased body temperature which expresses itself as fever. It is therefore called an endogenous pyrogen. ...
Ãâó: en.wikipedia.org/wiki/IL-1
IL-1 interleukin-1. A type of biological response modifier that stimulates immune system cells that fight disease, and is involved in inflammatory responses. There are two forms of IL-1, IL-1 alfa and IL-1 beta. Both forms of IL-1 are produced by the body, and can also be made in the laboratory.
Ãâó: www.stjude.org/glossary
IL-1 Produced by activated macrophages, endothelial cells, and B cells, IL-1 is a cytokine that induces inflammatory responses. As a proinflammatory cytokine, IL-1 has a role in immune, degradative, and growth-promoting processes. Belonging to this class of cytokines, IL-1?and IL-1a are agonists while IL-1Ra is an antagonist of the IL-1 receptor.
Ãâó: www.jco.org/cgi/glossarylookup
IL-1 one of the pro-inflammatory cytokines in the immune system thought to play a role in the disease process of RA, including bone erosion; the IL-1 receptor is the target of a new BRM, anakinra.
Ãâó: www.raacademy.com/glossary/Glossary.jsp
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