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IGF <growth factor> Insulin like growth factors I and II are polypeptides with considerable sequence similarity to insulin.
They are capable of eliciting the same biological responses, including mitogenesis in cell culture. On the cell surface, there are two types of insulin like growth factor receptor, one of which closely resembles the insulin receptor (which is also present).
Insulin like growth factor I = somatomedin A = somatomedin C
Insulin like growth factor II = MSA (Multiplication stimulating activity).
Insulin like growth factor 1 is released from the liver in response to growth hormone.
Acronym: IGF
(18 Nov 1997)
IGFBP-2 protease <enzyme> Igfbp - insulin-like growth factor binding protein; decreases the extracellular levels of igfbp-2 which allows more free igf to interact with its receptors and promote airway smooth muscle cell proliferation; its chemical nature has not been identified 9/95
Registry number: EC 3.4.-
(26 Jun 1999)
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