| Gell and Coombs Classification | A classification system that differentiates the 4 types of hypersensitivity reactions: Type I: anaphylactic reactions, Type II: cytotoxic reactions, Type III: immune complex reactions, and Type IV: cell-mediated reactions. (05 Mar 2000) |
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| Gell, P | <person> British immunologist. See: Gell and Coombs reactions. (05 Mar 2000) |
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| International Classification of Impairments Disabilities and Handicaps | A WHO-sponsored numerical taxonomy of the impairments, disabilities and handicaps consequent upon injury and disease. (05 Mar 2000) |
| Carey Coombs murmur | A blubbering apical middiastolic murmur occurring in the acute stage of rheumatic mitral valvulitis and disappearing as the valvulitis subsides. Synonym: Coombs murmur. (05 Mar 2000) |
| Coombs, Carey | <person> English physician, 1879-1932. See: Coombs murmur. (05 Mar 2000) |
| Coombs murmur | A blubbering apical middiastolic murmur occurring in the acute stage of rheumatic mitral valvulitis and disappearing as the valvulitis subsides. Synonym: Coombs murmur. (05 Mar 2000) |
| coombs' reaction | An immunological lab test to detect antibodies which attack the red blood cells of its own body (called autoantibodies). The test is important to the diagnosis of certain blood disorders. The test first reacts red blood cells with serum from the test individual, then with antibodies to the autoantibodies. If the autoantibodies exist, they will bind to the red blood cells. When the antibodies to the autoantibodies are added, they will bind the autoantibodies (still attached to the red blood cells) and cause the red blood cells to clump together. Large clumps of red blood cells indicate that the autoantibodies exist, absence of the clumps indicates that they don't. (09 Oct 1997) |
| Coombs, Robin | <person> English veterinarian and immunologist, *1921. See: Gell and Coombs reactions, Coombs' serum, Coombs' test, direct Coombs' test, indirect Coombs' test. (05 Mar 2000) |
| Coombs' serum | Serum from a rabbit or other animal previously immunised with purified human globulin to prepare antibodies directed against IgG and complement; used in the direct and indirect Coombs' tests. Synonym: Coombs' serum. (05 Mar 2000) |
| coombs' test | Haemagglutination test in which coombs' reagent (antiglobulin, or anti-human globulin rabbit immune serum) is added to detect incomplete (non-agglutinating, univalent, blocking) antibodies coating erythrocytes. The direct test is applied to red cells which have been coated with antibody in vivo (e.g., in haemolytic disease of newborn, autoimmune haemolytic anaemia, and transfusion reactions). The indirect test is applied to serum to detect the presence of antibody (e.g., in detection of incompatibility in cross-matching tests, detection and identification of irregular antibodies, and in detection of antibodies not identifiable by other means). (12 Dec 1998) |
| direct Coombs' test | A test for detecting sensitised erythrocytes in erythroblastosis foetalis and in cases of acquired immune haemolytic anaemia: the patient's erythrocytes are washed with saline to remove serum and unattached antibody protein, then incubated with Coombs' anti-human globulin (usually serum from a rabbit or goat previously immunised with human globulin); after incubation, the system is centrifuged and examined for agglutination, which indicates the presence of so-called incomplete or univalent antibodies on the surface of the erythrocytes. (05 Mar 2000) |
| indirect Coombs' test | A test routinely performed in cross-matching blood or in the investigation of transfusion reaction: test for patient's serum is incubated with a suspension of donor erythrocytes; if specific antibodies are present, they become attached to the antigen in donor's cells; after a washing with saline, Coombs' antihuman globulin is added; agglutination at this point indicates that antibodies present in the original test serum had indeed become attached to donor erythrocytes. (05 Mar 2000) |
| adansonian classification | The classification of organisms based on giving equal weight to every character of the organism; this principle has its greatest application in numerical taxonomy. Origin: M. Adanson (05 Mar 2000) |
| Angle's classification of malocclusion | A classification of different types of malocclusion, based on the mesiodistal relationship of the permanent molars upon their eruption and locking, and comprised of three classes; Class I: normal relationship of the jaws, wherein the mesiobuccal cusp of the maxillary first molar occludes in the buccal groove of the mandibular first permanent molar; Class II: distal relationship of the mandible, wherein the distobuccal cusp of the maxillary first permanent molar occludes in the buccal groove of the mandibular first molar, and further classified as Division 1, labioversion of maxillary incisor teeth, and Division 2, linguoversion of maxillary central incisors, both of which may be unilateral conditions; Class III: mesial relationship of the mandible, wherein the mesiobuccal cusp of the maxillary first molar occludes in the embrasure between the mandibular first and second permanent molars, further classified as a unilateral condition. (05 Mar 2000) |
| aortic dissection: classification | <radiology> DeBakey: I ascending aorta to arch with or without descending aorta (30%), II ascending aorta only (20%), III descending aorta to thoracic aorta (50%), Stanford: A involvement of ascending aorta (regardless of origin), B aortic arch and distal aorta see also: aetiology mnemomics: 1 A.D. (DeBakey), A = Ascending (12 Dec 1998) |
| Arneth classification | A classification of the polymorphonuclear neutrophils according to the number of their nuclear lobes. See: Arneth stages. (05 Mar 2000) |