| gentamicin | <drug> A group of aminoglycoside antibiotics produced by Micromonospora spp. Members include the closely related gentamicin compounds C1, C2 and C1a, together with gentamicin A. They inhibit protein synthesis on 70S ribosomes by binding to the 23S core protein of the small subunit, that is responsible for binding mRNA. Mode of action similar to that of kanamycin, neomycin, paromomycin, spectinomycin and streptomycin. Active against strains of the bacterium Pseudomonas aeruginosa. (18 Nov 1997) |
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| gentamicin 2'-N-acetyltransferase | <enzyme> An aminoglycoside acetyltransferase; isolated from providencia stuartii; genbank l06156 Registry number: EC 2.3.1.59 Synonym: aac(2')-ia, 2'-n-acetyltransferase, providencia stuartii (26 Jun 1999) |
| gentamicin 2''-nucleotidyltransferase | <enzyme> Chemical name: aminoglycoside 2''-adenylyltransferase Registry number: EC 2.7.7.46 Synonym: gentamycin adenylase, gentamycin adenylyltransferase, aminoglycoside adenylyltransferase, aminoglycoside 2''-o-nucleotidyltransferase, 2''-o-adenylyltransferase, aada2 gene product (26 Jun 1999) |
| sisomicin-gentamicin resistance ribosomal RNA methylase | <enzyme> Catalyses the methylation of 30s ribosomal units to confer sisomicin-gentamicin resistance in micromonospora zionensis Registry number: EC 2.1.1.- Synonym: sgm gene product, sgm methylase (26 Jun 1999) |