| Friend murine erythroleukaemia cell | <cell culture> Lines of mouse erythroblasts transformed by the Friend virus, that can be induced to differentiate terminally, producing haemoglobin, by various agents such as dimethyl sulphoxide. (18 Nov 1997) |
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| Friend murine leukaemia virus | <virology> Murine leukaemia virus isolated by Charlotte Friend in 1956 whilst attempting to transmit the Erlich ascites tumour by cell free extracts. Causes an unusual erythroblastosis like leukaemia, in which anaemia is accompanied by large numbers of nucleated red cells in blood. does not carry a host derived oncogene, but seems to induce tumours by proviral insertion into specific regions of host genome. (18 Nov 1997) |
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| erythroleukaemia | <haematology, oncology> A rare cancer of the blood affecting immature red blood cells. Origin: Gr. Haima = blood (13 Nov 1997) |
| Friend, Charlotte | <person> U.S. Microbiologist, *1921. See: Friend disease, Friend virus, Friend leukaemia virus. (05 Mar 2000) |
| Friend disease | Mouse leukaemia caused by the Friend leukaemia virus, a member of the family Retroviridae. (05 Mar 2000) |
| Friend helper virus | <virology> Mouse (lymphoid) leukaemia virus present in stocks of Friend virus, that was believed at one time to assist its replication. Molecular cloning of Friend virus has since shown that it is nondefective. (18 Nov 1997) |
| Friend leukaemia virus | A murine leukaemia virus producing leukaemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects dba/2 and swiss mice. (12 Dec 1998) |
| Friend spleen focus forming virus | <virology> Defective virus found in certain strains of Friend virus, detected by its ability to form foci in spleens of mice and believed to be responsible in those strains for the production of a leukaemia associated with polycythaemia rather than anaemia. (18 Nov 1997) |
| friend virus | A murine leukaemia virus producing leukaemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects dba/2 and swiss mice. (12 Dec 1998) |
| Abelson murine leukaemia virus | A retrovirus belonging to the Type C retrovirus group subfamily (family Oncovirinae) which is associated with leukaemia and produces in vitro transformation of mouse cells. (05 Mar 2000) |
| gastroenteritis virus, murine | A species of the coronavirus genus causing hepatitis in mice. Four strains have been identified as mhv 1, mhv 2, mhv 3, and mhv 4 (also known as jhm, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis). (12 Dec 1998) |
| Moloney murine leukaemia virus | <molecular biology, virology> Replication competent retrovirus (Oncovirinae) that causes leukaemia in mice, isolated by Moloney from cell free extracts made from a transplantable mouse sarcoma. (18 Nov 1997) |
| Moloney murine sarcoma virus | <molecular biology, virology> Replication defective retrovirus, source of the oncogene v mos, responsible for inducing fibrosarcomas in vivo and transforming cells in culture. (18 Nov 1997) |
| murine | Pertaining to mice. (18 Nov 1997) |
| murine acquired immunodeficiency syndrome | <syndrome> Acquired defect of cellular immunity that occurs in mice infected with mouse leukaemia viruses (mulv). The syndrome shows striking similarities with human aids and is characterised by lymphadenopathy, profound immunosuppression, enhanced susceptibility to opportunistic infections, and B-cell lymphomas. (12 Dec 1998) |
| murine hepatitis | A form of hepatitis in mice due to synergism between the mouse hepatitis virus and Eperythrozoon coccoides. Synonym: murine hepatitis. (05 Mar 2000) |