| Friend disease | Mouse leukaemia caused by the Friend leukaemia virus, a member of the family Retroviridae. (05 Mar 2000) |
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| Friend, Charlotte | <person> U.S. Microbiologist, *1921. See: Friend disease, Friend virus, Friend leukaemia virus. (05 Mar 2000) |
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| Friend helper virus | <virology> Mouse (lymphoid) leukaemia virus present in stocks of Friend virus, that was believed at one time to assist its replication. Molecular cloning of Friend virus has since shown that it is nondefective. (18 Nov 1997) |
| Friend leukaemia virus | A murine leukaemia virus producing leukaemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects dba/2 and swiss mice. (12 Dec 1998) |
| Friend murine erythroleukaemia cell | <cell culture> Lines of mouse erythroblasts transformed by the Friend virus, that can be induced to differentiate terminally, producing haemoglobin, by various agents such as dimethyl sulphoxide. (18 Nov 1997) |
| Friend murine leukaemia virus | <virology> Murine leukaemia virus isolated by Charlotte Friend in 1956 whilst attempting to transmit the Erlich ascites tumour by cell free extracts. Causes an unusual erythroblastosis like leukaemia, in which anaemia is accompanied by large numbers of nucleated red cells in blood. does not carry a host derived oncogene, but seems to induce tumours by proviral insertion into specific regions of host genome. (18 Nov 1997) |
| Friend spleen focus forming virus | <virology> Defective virus found in certain strains of Friend virus, detected by its ability to form foci in spleens of mice and believed to be responsible in those strains for the production of a leukaemia associated with polycythaemia rather than anaemia. (18 Nov 1997) |
| friend virus | A murine leukaemia virus producing leukaemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects dba/2 and swiss mice. (12 Dec 1998) |
| aaa disease | Endemic anaemia of ancient Egypt, ascribed in the Papyrus Ebers to intestinal infestation with ancylostoma; now called ancylostomiasis. (05 Mar 2000) |
| ABO haemolytic disease of the newborn | Erythroblastosis foetalis due to maternal-foetal incompatibility with respect to an antigen of the ABO blood group; the foetus possesses A or B antigen which is lacking in the mother, and the mother produces immune antibody which causes haemolysis of foetal erythrocytes. (05 Mar 2000) |
| accumulation disease | A disease characterised by abnormal accumulation of a metabolic product in certain cells and tissues; examples include the mucopolysaccharidoses, lipoidoses. (05 Mar 2000) |
| Acosta's disease | A condition that results from prolonged exposure to high altitude. Symptoms include a continuous dry cough, shortness of breath, poor exercise tolerance, dizziness, headache, sleep difficulty, anorexia, confusion, fatigue and a rapid pulse. Treatment includes the immediate movement to a lower altitude. Prophylaxis has been accomplished successfully with the use of acetazolamide (Diamox). (27 Sep 1997) |
| acquired immunodeficiency disease | Acquired immunodeficiency disease: Disease caused by infection with the human immunodeficiency virus (HIV). (12 Dec 1998) |
| acute disease | Disease having a short and relatively severe course. (12 Dec 1998) |
| Adams-Stokes disease | <syndrome> Transient asystole or ventricular fibrillation in the presence of atrioventricular block. (12 Dec 1998) |
| Addison-Biermer disease | <haematology> A form of anaemia (low red blood cell counts) that results when the bone marrow fails to produce adequate numbers of red blood cells due to a deficiency in vitamin B12. Intrinsic factor, necessary for normal B12 absorption, may be the underlying cause for B12 deficiency if is not produced in the gastric glands (in the stomach). Origin: Gr. Haima = blood (27 Sep 1997) |