| anemia | <haematology> Too few red blood cells in the bloodstream, resulting in insufficient oxygen to tissues and organs. Origin: Gr. Haima = blood (16 Dec 1997) |
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| genetic complementation | <genetics> The reappearance of wild-type characteristics in a cell or organism that has had two distinct mutations on the same chromosome. Two normal versions of two different mutant genes on different chromosomes affecting the same phenotype which, when inherited together, results in the wild-type phenotype despite the presence of mutant copies of the genes. (09 Oct 1997) |
| genetic complementation test | A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell. (12 Dec 1998) |
| complementation | <cell biology> The ability of a mutant chromosome to restore normal function to a cell that has a mutation in the homologous chromosome when a hybrid or heterokaryon is formed the explanation being that the mutations are in different cistrons and between the two a complete set of normal information is present. (18 Nov 1997) |
| complementation-fixation test | <investigation> A test for the presence of antibodies in a serum, based on whether an antigen and complement, when put together with some red blood cells, are able to destroy them. If the red blood cells are destroyed, then antibodies were not present to prevent it. If the red blood cells are not destroyed, then antibodies were present to combine with the antigen and bind the complement, making them unable to attack the red blood cells. (09 Oct 1997) |
| intergenic complementation | Complementation between pieces of genetic material that regulate the same function, such as a multienzyme pathway, but have defects in regions of separate genetic function; such complementation permits synthesis of a normal end-product. (05 Mar 2000) |
| intragenic complementation | Complementation between pieces of genetic material, each of which has a different defect within the same locus; the resultant product of each is defective and nonfunctional, but the defective products may associate to produce a product which has some activity. (05 Mar 2000) |
| pancytopenia, fanconi | A genetic (inherited) disease with progressive decline in blood cells and a tendency to leukaemia. Also known as fanconi anaemia. (12 Dec 1998) |
| De Toni-Fanconi syndrome | Lysosomal storage disorders of unknown molecular defect, characterised by widespread deposition of cystine crystals in reticuloendothelial cells. (12 Dec 1998) |
| Fanconi, Guido | <person> Swiss paediatrician, 1892-1979. See: Fanconi's anaemia, Fanconi's pancytopenia, Fanconi's syndrome, De Toni-Fanconi syndrome, Lignac-Fanconi syndrome. (05 Mar 2000) |
| Fanconi's anaemia | <haematology> A rare inherited type of aplastic anaemia which carries an increased risk to the patient of developing leukaemia. May be treated by bone marrow transplant. Origin: Gr. Haima = blood (13 Nov 1997) |
| Fanconi's pancytopenia | fanconi's anaemia |
| Fanconi's syndrome | <syndrome> A group of conditions with characteristic disorders of renal tubular function, which may be classified as: 1. Cystinosis, an autosomal recessive disease of early childhood. 2. Adult Fanconi syndrome, a rare hereditary form, probably due to a recessive gene different from that found in cystinosis, characterised by the tubular malfunction seen in cystinosis and by osteomalacia, but without cystine deposit in tissues. 3. Acquired Fanconi syndrome, which may be associated with multiple myeloma or may result from chemical poisoning, injury, or persisting damage of proximal tubular epithelium due to various causes, leading to multiple defects of tubular function. (05 Mar 2000) |
| Fanconi syndrome | <syndrome> Transport disease (recessive defect) in which the renal reabsorption of several substances (phosphate, glucose, amino acids) is impaired. (18 Nov 1997) |
| Lignac-Fanconi syndrome | Lysosomal storage disorders of unknown molecular defect, characterised by widespread deposition of cystine crystals in reticuloendothelial cells. (12 Dec 1998) |