| fos | <oncogene> An oncogene, identified in a mouse osteosarcoma, encoding a transcription factor. The product of this oncogene works with the product of another oncogene, the jun oncogene, to abnormally change the rate of transcription of certain other genes. Fos and jun proteins dimerise via a leucine zipper to form the AP 1 transcription factor. (24 Mar 1998) |
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| Fos kinase | <enzyme> A nerve growth factor-regulated kinase from pc12 cells; phosphorylates c-fo protein at a site near its c terminus; mw 37 kD; may play a role in the regulation of the transcriptional repressive activity of c-fos Registry number: EC 2.7.10.- (26 Jun 1999) |
| fos-related antigen | <molecular biology> A group of phosphoproteins found in the cell nucleus which are structurally similar to the fos oncogene's gene product. (06 Mar 1998) |
| foscarnet | <drug> An antiviral drug FDA-approved to treat CMV infection in the retina and elsewhere in the body. Also has activity against herpes simplex virus, including acyclovir-resistant strains. Possible adverse side effects include kidney toxicity, seizures, anaemia, nausea and skin rashes. (06 Mar 1998) |
| Fosdick, Leonard | <person> U.S. Chemist, *1903. See: Fosdick-Hansen-Epple test. (05 Mar 2000) |
| Fosdick-Hansen-Epple test | A test for determining dental caries activity based on a solution of powdered human enamel in a saliva-glucose-enamel mixture. (05 Mar 2000) |
| fosfomycin | <drug> An antibiotic that works by interfering with bacterial cell wall synthesis. (06 Mar 1998) |
| Foshay test | An intradermal test for cat-scratch disease or tularaemia, using material prepared from suppurative lymph nodes of persons known to have had the disease. (05 Mar 2000) |
| Foshay, Lee | <person> U.S. Bacteriologist, 1896-1961. See: Foshay test. (05 Mar 2000) |
| fosinopril | <chemical> A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat. Pharmacological action: angiotensin-converting enzyme inhibitors, antihypertensive agents. Chemical name: L-Proline, 4-cyclohexyl-1-(((2-methyl-1-(1-oxopropoxy)propoxy)(4-phenylbutyl)phosphinyl)acetyl)-, (1(S*(R*)),2alpha,4beta)- (12 Dec 1998) |
| fossa | Origin: L, a ditch. See Fosse. <anatomy, ornithology> A pit, groove, cavity, or depression, of greater or less depth; as, the temporal fossa on the side of the skull; the nasal fossae containing the nostrils in most birds. Source: Websters Dictionary (01 Mar 1998) |
| fossa acetabuli | A depressed area in the floor of the acetabulum superior to the acetabular notch. Synonym: fossa acetabuli. (05 Mar 2000) |
| fossa anthelicis | The depression on the medial surface of the auricle that corresponds to the anthelix. Synonym: fossa anthelicis, periconchal sulcus. (05 Mar 2000) |
| fossa axillaris | <anatomy> The underarm area. (16 Dec 1997) |
| fossa canina | A depression on the anterior surface of the maxilla below the infraorbital foramen and on the lateral side of the canine eminence. Synonym: fossa canina. (05 Mar 2000) |
| genes, fos | Retrovirus-associated DNA sequences (fos) originally isolated from the finkel-biskis-jinkins (fbj-msv) and finkel-biskis-reilly (fbr-msv) murine sarcoma viruses. The proto-oncogene protein c-fos codes for a nuclear protein which is involved in growth-related transcriptional control. The insertion of c-fos into fbj-msv or fbr-msv induces osteogenic sarcomas in mice. The human c-fos gene is located at 14q21-31 on the long arm of chromosome 14. (12 Dec 1998) |
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| proto-oncogene proteins c-fos | Cellular DNA-binding proteins encoded by the c-fos genes (genes, fos). They are involved in growth-related transcriptional control. C-fos combines with c-jun (proto-oncogene proteins c-jun) to form a c-fos/c-jun heterodimer (transcription factor ap-1) that binds to the tre (tpa-responsive element) in promoters of certain genes. (12 Dec 1998) |
| oncogene proteins v-fos | Transforming proteins coded by fos oncogenes. These proteins have been found in the finkel-biskis-jinkins (fbj-msv) and finkel-biskis-reilly (fbr-msv) murine sarcoma viruses which induce osteogenic sarcomas in mice. The fbj-msv v-fos gene encodes a p55 kD protein and the fbr-msv v-fos gene encodes a p75 kD fusion protein. (12 Dec 1998) |