| tumor | 1. <oncology> An abnormal mass of tissue that results from excessive cell division that is uncontrolled and progressive, also called a neoplasm. Tumours perform no useful body function. They may be either benign (not cancerous) or malignant. 2. Swelling, one of the cardinal signs of inflammations, morbid enlargement. Origin: L. Tumere = to swell (12 May 1997) |
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| tumor marker | <investigation, oncology> A substance in the body that usually indicates the presence of cancer. These markers are usually specific to certain types of cancer and are usually found in the blood or other tissue samples. Examples are alphafetoprotein (AFP), human chorionic gonadotropin, and lactate dehydrogenase (LDH). They may be indicators of tumour stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids. (18 Jul 2002) |
| tumor necrosis factor | <cytokine> Originally described as a tumour inhibiting factor in the blood of animals exposed to bacterial lipopolysaccharide or Bacille Calmette-Guerin. Preferentially kills tumour cells in vivo and in vitro, causes necrosis of certain transplanted tumours in mice and inhibits experimental metastases. Human Tumour Necrosis factor alpha is a protein of 157 amino acids and has a wide range of pro inflammatory actions. Usually considered a cytokine. Synonym: cachectin. Acronym: TNF (13 Nov 1997) |
| Roach, F Ewing | <person> U.S. Prosthodontist, 1868-1960. See: Roach clasp. (05 Mar 2000) |
| sarcoma, ewing's | A malignant tumour of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. There are conspicuous foci of necrosis in association with irregular masses of small, regular, rounded or ovoid cells with very scanty cytoplasm. The tumour occurs usually before the age of 20, about twice as frequently in males as in females. (12 Dec 1998) |
| Ewing, James | <person> U.S. Pathologist, 1866-1943. See: Ewing's sarcoma, Ewing's tumour. (05 Mar 2000) |
| Ewing, James H | <person> Pathologist, 1798-1827. See: Ewing's sign. (05 Mar 2000) |
| ewing sarcoma | <radiology> Small, round-cell sarcoma of mesenchyme of medullary bone, age 5 - 14 yrs, most lethal of all primary bone tumours, any bone, less than 20 years of age: long bones, greater than 20 years of age: flat bones (where there's still red marrow), purely lytic (62%), purely sclerotic (15%), periosteal reaction (onion-skin or perpendicular), similar lesion at different age, less than 5 years of age -- neuroblastoma, greater than 30 years of age -- metastasis, reticulum cell sarcoma (12 Dec 1998) |
| Ewing's sarcoma | <oncology, tumour> A malignant primary bone tumour that arises most commonly in the first three decades of life. It is highly malignant (prone to spread) and often requires treatment with some combination of radiation therapy and chemotherapy. (27 Sep 1997) |
| Ewing's sign | <clinical sign> Dullness on percussion to the inner side of the angle of the left scapula, denoting an accumulation of fluid in the pericardium behind the heart, tenderness at the upper inner angle of the orbit at the point of attachment of the pulley of the superior oblique muscle, denoting closure of the outlet of the frontal sinus. (05 Mar 2000) |
| Ewing's tumour | A malignant primary bone tumour that arises most commonly in the first three decades of life. It is highly malignant (prone to spread) and often requires treatment with some combination of radiation therapy and chemotherapy. (27 Sep 1997) |