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entacapone a selective, reversible inhibitor of catechol O-methyltransferase, the enzyme mainly responsible for levodopa metabolism in the brain and periphery in the presence of carbidopa; used in conjunction with levodopa and carbidopa to enhance dopaminergic stimulation of the brain and the antiparkinsonian activity of levodopa in the treatment of idiopathic Parkinson's disease, administered orally.
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