| ERKs | Mitogen activated protein kinases. (ERKs: externally regulated kinases) Serine threonine kinases that are activated when quiescent cells are treated with mitogens and therefore potentially transmit signal for entry into cell cycle. One target is trancription factor p62TCF. MAP kinase itself can be phosphorylated by MAP kinase kinase and this may in turn be controlled by RAF 1. Confusingly, do phosphorylate microtubule-associated proteins. (18 Nov 1997) |
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| PK40(erk) protein kinase | <enzyme> A member of the erk family of serine/threonine-proline kinases; hyperphosphorylates tau protein in neurofibrillary tangles of alzheimer's disease subsequent to phosphorylation by camp-dependent protein kinase a; has been sequenced Registry number: EC 2.7.1.- Synonym: pk40(erk2), erk2 brain kinase pk40 (26 Jun 1999) |
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