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EGF <growth factor> A mitogenic polypeptide initially isolated from male mouse submaxillary gland.
The name refers to the early bioassay, but epidermal growth factor is active on a variety of cell types, especially but not exclusively epithelial. Human equivalent originally named urogastrone owing to its hormone activity.
Acronym: EGF
(18 Nov 1997)
EGF like domain Region of 30-40 amino acids containing 6 cysteines found originally in EGF and also in a range of proteins involved in cell signalling.
Examples: TGF _, amphiregulin, urokinase, tissue plasminogen activator, complement C6 C9, fibronectin, laminin (each subunit at least 13 times), nidogen, selectins. It is also found in the Drosophila gene products: Notch (36 times) Delta, Slit, Crumbs, Serrate.
(18 Nov 1997)
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