| eflornithine | <chemical> 2-(difluoromethyl)-dl-ornithine. An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway. As a result of this inhibition of polyamine synthesis, the compound is effective in preventing cancer formation in many organ systems, inhibiting cancer growth, and reducing tumour size. It also has synergistic action with other antineoplastic agent. In addition, it has been found effective as a trypanocidal agent. Pharmacological action: antineoplastic agent, enzyme inhibitors, trypanocidal agents. Chemical name: Ornithine, 2-(difluoromethyl)- (12 Dec 1998) |
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| eflornithine hydrochloride | 2-(Difluoromethyl)-dl-ornithine monohydrochloride, monohydrate;an antineoplastic and antiprotozoal orphan drug used in the treatment of Pneumocystis carinii pneumonia in AIDS and of Trypanosoma brucei gambiense sleeping sickness. (05 Mar 2000) |