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eflornithine <chemical> 2-(difluoromethyl)-dl-ornithine. An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway. As a result of this inhibition of polyamine synthesis, the compound is effective in preventing cancer formation in many organ systems, inhibiting cancer growth, and reducing tumour size. It also has synergistic action with other antineoplastic agent. In addition, it has been found effective as a trypanocidal agent.
Pharmacological action: antineoplastic agent, enzyme inhibitors, trypanocidal agents.
Chemical name: Ornithine, 2-(difluoromethyl)-
(12 Dec 1998)
eflornithine hydrochloride 2-(Difluoromethyl)-dl-ornithine monohydrochloride, monohydrate;an antineoplastic and antiprotozoal orphan drug used in the treatment of Pneumocystis carinii pneumonia in AIDS and of Trypanosoma brucei gambiense sleeping sickness.
(05 Mar 2000)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 1 ÆäÀÌÁö: 1
  • Eflornithine - »õâ An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway.
    Synonyms : DL-alpha-Difluoromethylornithine, Eflornithine Hydrochloride, Eflornithine Monohydrochloride, Monohydrate, MDL-71, 782 A, Ornidyl, RMI 71782, Vaniqa, Women First Brand of Eflornithine Hydrochloride, alpha-Difluoromethyl Ornithine, 71782, RMI, MDL 71, 782 A
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eflornithine hydrochloride Eflornithine is a drug developed by Aventis, which has various uses. It was discovered during studies for cancer medication; while it has no significant effects in malignancies, it was found to be effective in combatting African trypanosomiasis (sleeping sickness), in particularthe West African form. It may replace the highly toxic melarsoprol. Supplies of Eflornithine are limited as Aventis no longer manufactures it due to low profit margins. ...
Ãâó: en.wikipedia.org/wiki/Eflornithine_hydrochloride
eflornithine Eflornithine is a drug developed by Aventis, which has various uses. It was discovered during studies for cancer medication; while it has no significant effects in malignancies, it was found to be effective in combatting African trypanosomiasis (sleeping sickness), in particularthe West African form. It may replace the highly toxic melarsoprol. Supplies of Eflornithine are limited as Aventis no longer manufactures it due to low profit margins. ...
Ãâó: en.wikipedia.org/wiki/Eflornithine
eflornithine An investigational drug that reduces the growth of tumor cells and may stop abnormal cells from turning into cancer cells.
Ãâó: nydailynews.healthology.com/nydailynews/15836.htm
eflornithine A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals.
Ãâó: goldbamboo.com/glossary-1e.html
eflornithine An antiprotozoal drug that is being studied for cancer prevention.
Ãâó: www.spineuniverse.com/community/cancerdictionary.h...
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