| Donath-landsteiner | <investigation> A serologic blood test used to detect antibody in serum in cases of suspected paroxysmal cold haemoglobinuria. The antibody is directed toward the P-antigen complex which is located on the surface of red blood cells. In some way, cold temperatures trigger the antibody to bind to this site. (15 Nov 1997) |
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| Donath-Landsteiner cold autoantibody | An autoantibody of the IgG class responsible for paroxysmal cold haemoglobinuria; it is adsorbed to red cells only at temperatures of 20캜 or lower, causing the red cells to lyse in the presence of complement at higher temperatures; it has only slight agglutinating properties in spite of its marked lytic activity, and has a specificity within the blood group P; it is also occasionally present for short periods of time following measles and other infections, and formerly was frequently associated with syphilis. Synonym: cold haemolysin. (05 Mar 2000) |
| Donath-Landsteiner phenomenon | The haemolysis which results in a sample of blood of a subject of paroxysmal haemoglobinuria when the sample is cooled to around 5캜 and then warmed again. (05 Mar 2000) |