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Didanosine - 새창
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Synonyms : Bristol-Myers Brand of Didanosine, Bristol-Myers Squibb Brand of Didanosine, NSC-612049, Videx, 2', 3' Dideoxyinosine, Bristol Myers Brand of Didanosine, Bristol Myers Squibb Brand of Didanosine, NSC 612049, NSC612049
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