| clathrin adaptor proteins | <cell biology> Family of proteins that bind to clathrin and promote its assembly into vesicle coats. Different adaptor proteins are associated with coated vesicles of Golgi or plasma membrane origin. (18 Nov 1997) |
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| second signaling system | <psychology> Pavlovian term for speech in which words are considered to be the second signals capable of producing conditioned responses. (05 Mar 2000) |
| hydrophilic signaling molecule | <molecular biology> A type of molecule which, because it is easily dissolved in water (it is hydrophilic), can easily move through cell membranes and thus can be secreted from one cell and move into a target cell where it triggers a particular event. Many hormones and growth factors are hydrophilic signaling molecules. (09 Oct 1997) |
| adaptor | <molecular biology> Short synthetic oligonucleotide strands that have one stickyend and oneblunt end, the blunt ends join to the blunt end of a DNA fragment, forming a new fragment with two sticky ends that can be more easily spliced into a vector. (13 Oct 1997) |
| adaptor hypothesis | A hypothesis, proposed by F.H.C. Crick, that an adaptor molecule must be present between the information-containing DNA and the protein being synthesised. (05 Mar 2000) |
| apple domain | <molecular biology> A consensus sequence, composed of 90 amino acids including 6 cysteines, that forms a characteristic, vaguely apple shaped, pattern via disulphide bridges. Shared by plasma kallikrein and coagulation factor XI, both serine proteases. (18 Nov 1997) |
| carboxy-terminal domain kinase | <enzyme> Protein kinase that phosphorylates the c-terminal repeat domain of the largest subunit of RNA polymerase II at serine residues Registry number: EC 2.7.1.- Synonym: ctd kinase, hs-ctd kinase, tfiih-associated ctd kinase (26 Jun 1999) |
| paired box domain | <molecular biology> Conserved domain of 128 amino acids, found in several developmentally regulated proteins in Drosophila (for example paired, gooseberry, Pox), mouse and human (for example Pax, HuP1, HuP48). (18 Nov 1997) |
| POU domain | <molecular biology> A conserved protein domain of around 150 amino acids, composed of a 20 amino acid homeobox domain and a larger POU specific domain and so is the target of some transcription factors. Named POU (Pit Oct Unc) after 3 such proteins: Pit 1 regulates expression of certain pituitary genes, Oct 1 and 2, that bind an octamer sequence in the promoters of histone H2A and some immunoglobulin genes and Unc 86, involved in nematode sensory neuron development. (31 Dec 1997) |
| SH3 domain-containing proline-rich kinase | <enzyme> A protein kinase which both phosphorylates ser and thr residues and has an sh3 domain; contains 847 amino acid residues; mol mass 92,688 da; genbank u07747 Registry number: EC 2.7.10.- Synonym: src-homology 3 domain-containing proline-rich kinase, sprk protein, sprk gene product (26 Jun 1999) |
| dinucleotide domain | A structural domain in certain proteins that binds NAD+ or NADP+. Synonym: dinucleotide domain. (05 Mar 2000) |
| domain | <molecular biology> Used to describe a part of a molecule or structure that shares common physico chemical features, for example hydrophobic, polar, globular, helical domains or properties for example DNA binding domain, ATP binding domain. (18 Nov 1997) |
| EGF like domain | Region of 30-40 amino acids containing 6 cysteines found originally in EGF and also in a range of proteins involved in cell signalling. Examples: TGF _, amphiregulin, urokinase, tissue plasminogen activator, complement C6 C9, fibronectin, laminin (each subunit at least 13 times), nidogen, selectins. It is also found in the Drosophila gene products: Notch (36 times) Delta, Slit, Crumbs, Serrate. (18 Nov 1997) |
| exit domain | <molecular biology> One of the two main binding sites on the ribosome molecule. The finished portion of the polypeptide being translated is attached to this site and leaves the ribosome from this site when the entire polypeptide is finished. (09 Oct 1997) |
| frequency domain | The expression of a function by its amplitude and phase at each component frequency, usually as determined by Fourier analysis. (05 Mar 2000) |